{"id":"W1990960492","doi":"10.1021/bc0341573","title":"Promotion of Peptide Antimicrobial Activity by Fatty Acid Conjugation","year":2004,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; Materials Research Science and Engineering Center, Harvard University; University of British Columbia; National Science Foundation","keywords":"Phosphatidylethanolamine; Chemistry; Peptide; Phosphatidylcholine; Conjugated system; Vesicle; Antimicrobial peptides; Membrane; Fatty acid; Conjugate; Circular dichroism; Antimicrobial; Biochemistry; Stereochemistry; Phospholipid; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001126427,0.000248859,0.0003346868,0.00002757664,0.0001463351,0.00001992755,0.0001940053,0.0003504636,0.0003718209],"category_scores_gemma":[0.00003404649,0.0002474651,0.0001452726,0.00009762552,0.0004627499,0.0001945491,0.00007821238,0.0002575323,0.0001149986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008251266,"about_ca_system_score_gemma":0.000093542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001790823,"about_ca_topic_score_gemma":0.000003765652,"domain_scores_codex":[0.9989233,0.00003415136,0.0002985483,0.0003628463,0.00004281058,0.000338336],"domain_scores_gemma":[0.999315,0.00001864595,0.0002850828,0.000265082,0.0000864397,0.00002975874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000125212,0.0003454451,0.0002121905,0.0001601015,0.00007896867,0.000001659127,0.00009126493,0.000008285098,0.9951327,0.0000487327,0.003220104,0.0005753455],"study_design_scores_gemma":[0.001493338,0.00006325845,0.00031627,0.0001047483,0.0000335611,0.0000462349,0.00005223579,5.010809e-7,0.9961193,0.0001002063,0.00141228,0.0002581234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961844,0.0001772356,0.0008587372,0.0004144551,0.0001950813,0.0002242065,0.0003083944,0.00009428342,0.001543171],"genre_scores_gemma":[0.9979866,0.00006515383,0.0002023504,0.0000599344,0.0000502251,0.00001133152,0.0004188519,0.00002357673,0.001181993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001807824,"threshold_uncertainty_score":0.9999977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01066500940481207,"score_gpt":0.2198258820500445,"score_spread":0.2091608726452324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}