{"id":"W1990960492","doi":"10.1021/bc0341573","title":"Promotion of Peptide Antimicrobial Activity by Fatty Acid Conjugation","year":2004,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; Materials Research Science and Engineering Center, Harvard University; University of British Columbia; National Science Foundation","keywords":"Phosphatidylethanolamine; Chemistry; Peptide; Phosphatidylcholine; Conjugated system; Vesicle; Antimicrobial peptides; Membrane; Fatty acid; Conjugate; Circular dichroism; Antimicrobial; Biochemistry; Stereochemistry; Phospholipid; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001931994,0.0004614391,0.0002164726,0.0001877611,0.0001272257,0.0002409307,0.0001606737,0.0003066504,0.0008474583],"category_scores_gemma":[0.0003097219,0.0001506681,0.0001741734,0.0001761647,0.0002066346,0.0002250914,0.0002449121,0.0002859252,0.0002477988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002105315,"about_ca_system_score_gemma":0.0001671211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002147892,"about_ca_topic_score_gemma":0.0002762445,"domain_scores_codex":[0.9998626,0.00004212371,0.0000127671,0.00001844997,0.00002769404,0.00003644238],"domain_scores_gemma":[0.9998193,0.00004331677,0.00005359409,0.00001820971,0.00003453714,0.00003100768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005294682,0.000008488571,0.00005759339,0.000019847,0.000002476582,0.00002066294,0.000005263943,0.00008187491,0.9989206,0.00003342035,0.000004593005,0.0007922809],"study_design_scores_gemma":[0.000008193314,0.0002156461,0.0003510911,0.000002153361,0.00000562072,0.00006470936,0.000003087194,0.0001966966,0.9987073,0.00001248027,0.0004305822,0.000002399128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965498,0.000542753,0.002037038,0.00002953255,0.00001060054,0.00002355344,0.00003015227,0.00002466744,0.0007518471],"genre_scores_gemma":[0.9941057,0.0005166129,0.004229314,0.00003390518,0.000005583714,0.00002782692,0.00008870067,0.00001237776,0.000979913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008474583,"threshold_uncertainty_score":0.002835035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01066500940481207,"score_gpt":0.2198258820500445,"score_spread":0.2091608726452324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}