{"id":"W1990980516","doi":"10.3747/co.22.2393","title":"Novel Agents and Associated Toxicities of Inhibitors of the PI3K/Akt/mTOR Pathway for the Treatment of Breast Cancer","year":2015,"lang":"en","type":"review","venue":"Current Oncology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Grand River Hospital; Hôpital Notre-Dame; Royal Victoria Regional Health Centre; University of Alberta; Sunnybrook Health Science Centre; HEC Montréal; Ottawa Hospital; BC Cancer Agency","funders":"Novartis Pharmaceuticals Canada","keywords":"PI3K/AKT/mTOR pathway; Everolimus; Medicine; Adverse effect; Protein kinase B; Breast cancer; Clinical trial; Cancer; Oncology; Pharmacology; Internal medicine; Signal transduction; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003570993,0.0004103857,0.001163139,0.003599409,0.0003149285,0.00120602,0.0006519122,0.0008583136,0.00696105],"category_scores_gemma":[0.005646111,0.0001593881,0.001703553,0.004161288,0.0003554193,0.001100855,0.0004715763,0.0005747692,0.0006510734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002026256,"about_ca_system_score_gemma":0.003523392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002691305,"about_ca_topic_score_gemma":0.01225432,"domain_scores_codex":[0.9973783,0.0007897872,0.0007909377,0.0001678543,0.0008025237,0.00007062683],"domain_scores_gemma":[0.9934489,0.003091946,0.002362332,0.00006693256,0.0009360125,0.00009384459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006610656,0.00007453064,0.00237861,0.1290556,0.0007440008,0.0007195454,0.0002110233,0.0004787979,0.001888802,0.001210204,0.0135578,0.84902],"study_design_scores_gemma":[0.0006639807,0.001745612,0.02805406,0.2109965,0.008000148,0.007377082,0.0009155283,0.0006151802,0.003217735,0.002053156,0.7362952,0.0000657213],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002015683,0.992794,0.0002451194,0.001051075,0.0001396415,0.0001047971,0.0004485421,0.000009576818,0.003191594],"genre_scores_gemma":[0.02918112,0.9645479,0.001841744,0.002140758,0.0004646752,0.0001583909,0.0005524532,0.000007776838,0.001105189],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00696105,"threshold_uncertainty_score":0.023287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1835086076406713,"score_gpt":0.4321129448288454,"score_spread":0.2486043371881742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}