{"id":"W1991029809","doi":"10.1016/j.ejca.2014.04.030","title":"Defining dose-limiting toxicity for phase 1 trials of molecularly targeted agents: Results of a DLT-TARGETT international survey","year":2014,"lang":"en","type":"article","venue":"European Journal of Cancer","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":76,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University; Princess Margaret Cancer Centre","funders":"","keywords":"Toxicity; Medicine; Limiting; Maximum tolerated dose; Clinical trial; Internal medicine; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.05986717,0.0001747495,0.001302502,0.0001508471,0.00003564851,0.00002873457,0.0005308797,0.00005000938,0.0001846565],"category_scores_gemma":[0.5323244,0.0001389221,0.0004807736,0.0001597601,0.000107729,0.00009173802,0.00007800655,0.0002645116,0.000001651814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004686039,"about_ca_system_score_gemma":0.0001123036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001040821,"about_ca_topic_score_gemma":0.00000439885,"domain_scores_codex":[0.986312,0.007922799,0.004625995,0.0002179803,0.0006970039,0.000224275],"domain_scores_gemma":[0.9414331,0.05098166,0.005704941,0.0002528401,0.001489018,0.000138494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.05344621,0.003441561,0.003357554,0.00113261,0.00604329,0.0001386389,0.002533259,0.0008112402,0.1526019,0.05526656,0.04827967,0.6729475],"study_design_scores_gemma":[0.159295,0.01188386,0.029993,0.006579747,0.002762818,0.00004069104,0.0003326581,0.007061787,0.3508113,0.4019623,0.02759565,0.001681122],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.1387737,0.0003676481,0.8519902,0.0004267048,0.00239652,0.0004223422,0.00230893,0.00001576373,0.003298162],"genre_scores_gemma":[0.4532683,0.00004879185,0.5459448,0.0001189816,0.0005312387,0.000002636712,0.000006073649,0.00004186487,0.00003737874],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.6712664,"threshold_uncertainty_score":0.9680646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5609379012588367,"score_gpt":0.5792507951494835,"score_spread":0.01831289389064683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}