{"id":"W1991031899","doi":"10.1074/jbc.m104387200","title":"Identification of Inactivation Determinants in the Domain IIS6 Region of High Voltage-activated Calcium Channels","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Identification (biology); Calcium; Voltage-dependent calcium channel; Domain (mathematical analysis); Chemistry; Cell biology; Biology; Mathematics; Botany","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004467746,0.00008842439,0.0001740835,0.00004004631,0.00002498639,0.00000707703,0.0001664088,0.0002172978,0.00001125734],"category_scores_gemma":[0.0002412872,0.00005744724,0.00009283791,0.0001691615,0.00008620997,0.000009430964,0.00002882287,0.0001206858,1.999005e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002153519,"about_ca_system_score_gemma":0.00002788955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005494028,"about_ca_topic_score_gemma":3.591646e-7,"domain_scores_codex":[0.9990159,0.00007164075,0.0005567891,0.0001193816,0.0001397391,0.00009656051],"domain_scores_gemma":[0.9988585,0.00002775438,0.000725545,0.0001437191,0.000217905,0.00002654059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004418093,0.0001390256,0.00530824,0.00001884761,0.00001150402,0.000006443304,0.00005339431,0.0003029322,0.9928992,0.000009428145,0.00004645542,0.000762702],"study_design_scores_gemma":[0.0004820791,0.0001974281,0.01664991,0.00002817701,0.000005610553,0.0001322911,0.0003222058,0.0001040918,0.9812591,0.0005653322,0.0001914937,0.00006229122],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904406,0.00005670261,0.009117601,0.0001444389,0.0001285356,0.00007342005,0.000002770508,0.000001601362,0.00003434717],"genre_scores_gemma":[0.999553,0.00007825116,0.00003170326,0.00003088918,0.000242855,0.000003394858,0.00001980167,0.000003998273,0.0000361451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01164013,"threshold_uncertainty_score":0.2342631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03293368600580358,"score_gpt":0.2759903861933866,"score_spread":0.243056700187583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}