{"id":"W1991056592","doi":"10.1016/j.bbapap.2010.09.014","title":"Inhibition of 17β-estradiol activation by CYP1A1: Genotype- and regioselective inhibition by St. John's Wort and several natural polyphenols","year":2010,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Deutsche Forschungsgemeinschaft","keywords":"Polyphenol; Regioselectivity; Genotype; Chemistry; Natural (archaeology); Pharmacology; Stereochemistry; Biology; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001604086,0.0003232645,0.000267193,0.00005652539,0.0001774283,0.00007609804,0.00006959997,0.0004437746,0.000001607061],"category_scores_gemma":[0.00004151972,0.000293227,0.00006438279,0.0001345991,0.0003145675,0.0000492885,0.0001032164,0.0004842795,4.449278e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001542703,"about_ca_system_score_gemma":0.00007670243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007658907,"about_ca_topic_score_gemma":0.000006811039,"domain_scores_codex":[0.9986515,0.00009448722,0.0002671161,0.0005586172,0.0001498428,0.0002784553],"domain_scores_gemma":[0.9992711,0.00001792226,0.0002652895,0.0002255023,0.00008873765,0.0001314818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000440655,0.0001165249,0.00001795635,0.00006466268,0.00008705333,8.564281e-7,0.0001496638,2.392044e-7,0.997677,0.0001201269,0.0004731558,0.0008521075],"study_design_scores_gemma":[0.00103895,0.0008399943,0.001217948,0.00006098667,0.00004261626,0.0000347004,0.00003064322,0.00008664963,0.9958078,0.0003125661,0.0001668161,0.0003602872],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997114,0.0003630021,0.0002146754,0.0006034374,0.00005195885,0.001387521,0.0001736495,0.00002451982,0.00006723314],"genre_scores_gemma":[0.9964953,0.000615318,0.001717405,0.0001400378,0.0001432185,0.00009993993,0.0006803781,0.00004179078,0.00006660969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001869156,"threshold_uncertainty_score":0.999952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002856104142744635,"score_gpt":0.2024991089692002,"score_spread":0.1996430048264556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}