{"id":"W1991071027","doi":"10.1038/oncsis.2014.37","title":"Chaetocin antileukemia activity against chronic myelogenous leukemia cells is potentiated by bone marrow stromal factors and overcomes innate imatinib resistance","year":2014,"lang":"en","type":"article","venue":"Oncogenesis","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"","keywords":"Chronic myelogenous leukemia; Cancer research; Bone marrow; Stromal cell; Imatinib; Stem cell; Haematopoiesis; Imatinib mesylate; Biology; Immunology; Leukemia; Cell biology; Myeloid leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001015618,0.0003145915,0.0002708464,0.0002550349,0.0001113812,0.0001737769,0.0001361509,0.0001758336,0.001116783],"category_scores_gemma":[0.0001001485,0.00008604503,0.0001748237,0.0001308662,0.0001631403,0.0001386322,0.0001815048,0.0004817693,0.0002109947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001384904,"about_ca_system_score_gemma":0.00017983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003059151,"about_ca_topic_score_gemma":0.0008817461,"domain_scores_codex":[0.9998994,0.00001859032,0.00001009006,0.0000127523,0.00002948399,0.00002969178],"domain_scores_gemma":[0.9999387,0.00001260485,0.00001501099,0.000005719447,0.000007725846,0.00002022012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001793974,0.00007161139,0.0002390701,0.00003922027,0.000005038527,0.00004326195,0.00001073913,0.00005397171,0.9966581,0.00007704058,0.00003737663,0.002585229],"study_design_scores_gemma":[0.0001327815,0.002144536,0.01376206,0.000009878851,0.00002722907,0.0004634511,0.00002478555,0.0008246696,0.9783301,0.00005140977,0.004220712,0.000008397898],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956012,0.001661039,0.0007622826,0.00007435942,0.00002529551,0.00004903476,0.0001511981,0.00005382412,0.001621745],"genre_scores_gemma":[0.9976795,0.0006647087,0.0005075459,0.00004126939,0.00001136243,0.00002798753,0.0003053289,0.000004710993,0.0007575325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001116783,"threshold_uncertainty_score":0.003736019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00901262803584609,"score_gpt":0.2336495664022351,"score_spread":0.224636938366389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}