{"id":"W1991102235","doi":"10.1021/bi002745n","title":"Reduction Precedes Cytidylyl Transfer without Substrate Channeling in Distinct Active Sites of the Bifunctional CDP-Ribitol Synthase from <i>Haemophilus influenzae</i>","year":2001,"lang":"en","type":"article","venue":"Biochemistry","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Phosphofructokinase 2; Ribitol; Biochemistry; Chemistry; Bifunctional; ATP synthase; Enzyme; Active site; Stereochemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002669585,0.0002671212,0.0002495412,0.0001256927,0.00009880257,0.0004751889,0.0002671357,0.0002850188,0.0004385361],"category_scores_gemma":[0.0002819916,0.0002179127,0.0002808583,0.0001012714,0.000216412,0.0002463305,0.0001872358,0.0005165139,0.0002775019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005798502,"about_ca_system_score_gemma":0.0002700404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001350204,"about_ca_topic_score_gemma":0.001165171,"domain_scores_codex":[0.999763,0.00003709929,0.00002098789,0.00006384365,0.00006855559,0.00004662085],"domain_scores_gemma":[0.9998159,0.00003867941,0.00004682272,0.00002000219,0.00003325735,0.00004537114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001016191,0.00001618666,0.0002294248,0.00001954083,0.000003788868,0.00002611389,0.00001359626,0.00006241717,0.9986135,0.0001432554,0.00001855515,0.000751934],"study_design_scores_gemma":[0.000009176987,0.00008042688,0.002705094,0.000003197835,0.000007492996,0.00009558664,0.00001873825,0.002002317,0.9945291,0.00005040238,0.0004915126,0.000006978761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952363,0.0006060723,0.003302449,0.0000563899,0.00001864966,0.00001526,0.0001529323,0.00005105619,0.0005608284],"genre_scores_gemma":[0.9961914,0.0001439074,0.002658909,0.00002462564,0.000003633023,0.00001150129,0.0003082993,0.00002118658,0.0006364876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001350204,"threshold_uncertainty_score":0.004207134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01511106529798641,"score_gpt":0.2325081028610125,"score_spread":0.217397037563026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}