{"id":"W1991102235","doi":"10.1021/bi002745n","title":"Reduction Precedes Cytidylyl Transfer without Substrate Channeling in Distinct Active Sites of the Bifunctional CDP-Ribitol Synthase from <i>Haemophilus influenzae</i>","year":2001,"lang":"en","type":"article","venue":"Biochemistry","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Phosphofructokinase 2; Ribitol; Biochemistry; Chemistry; Bifunctional; ATP synthase; Enzyme; Active site; Stereochemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000141852,0.0001988192,0.000204728,0.00003460142,0.0001201089,0.0000323197,0.0001945304,0.0001886045,0.0003019104],"category_scores_gemma":[0.00009303451,0.0001525588,0.00008851581,0.0002536638,0.0001791665,0.0001688164,0.00003322389,0.0002031984,0.000009289683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008188926,"about_ca_system_score_gemma":0.00009392676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002843049,"about_ca_topic_score_gemma":0.00009872513,"domain_scores_codex":[0.9986986,0.00004672576,0.0003255182,0.0004039668,0.0002983099,0.0002268915],"domain_scores_gemma":[0.9993796,0.00005104164,0.0001086165,0.0003056202,0.00009808237,0.00005705709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003900829,0.00005343068,0.007867153,0.00003247161,0.00001214871,0.000002020184,0.0002465759,0.0001809593,0.9909614,0.000008839227,0.00005602857,0.0001888685],"study_design_scores_gemma":[0.0004688526,0.00002330139,0.01552395,0.0001095752,0.00003359656,0.0000315556,0.0003175167,0.0001041389,0.9828172,0.0003438511,0.00005969114,0.0001667664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978374,0.0001641029,0.0001322014,0.00008761336,0.000568739,0.0001585137,0.000180863,0.00004680038,0.0008238125],"genre_scores_gemma":[0.9991014,0.00001355444,0.0001087558,0.00002665673,0.0005356458,0.00002375958,0.0000661883,0.00001436145,0.0001096944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008144222,"threshold_uncertainty_score":0.6221169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01511106529798641,"score_gpt":0.2325081028610125,"score_spread":0.217397037563026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}