{"id":"W1991105330","doi":"10.1124/mol.107.034884","title":"Desensitization of the Dopamine D1 and D2 Receptor Hetero-Oligomer Mediated Calcium Signal by Agonist Occupancy of Either Receptor","year":2007,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute on Drug Abuse","keywords":"Agonist; Desensitization (medicine); Homologous desensitization; Dopamine receptor D2; Chemistry; Receptor; Calcium; Endocrinology; Pharmacology; Internal medicine; Biophysics; Biochemistry; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003832277,0.0001993405,0.0002589437,0.00005804802,0.00006743244,0.000006725587,0.0001910436,0.0002304306,0.0003528029],"category_scores_gemma":[0.00004195783,0.0001641548,0.0001129455,0.0001736366,0.0002226893,0.000004603532,0.0001260853,0.0001256627,0.00000387297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001677879,"about_ca_system_score_gemma":0.00005053801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002750566,"about_ca_topic_score_gemma":0.000003182133,"domain_scores_codex":[0.9985761,0.0001958095,0.0004087547,0.0003287269,0.000186181,0.0003044245],"domain_scores_gemma":[0.9992408,0.00003495853,0.0002562305,0.0001923441,0.000175984,0.00009968316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002165448,0.00008794224,0.0006005301,0.00002975814,0.0001255454,0.000002540779,0.00004455592,0.0000242379,0.9950396,0.00003024397,0.002871364,0.0009271826],"study_design_scores_gemma":[0.0008739427,0.0002666616,0.0001362309,0.00001167588,0.0000560323,0.000008613116,0.00003784172,0.0000583712,0.9788387,0.00001058005,0.01953756,0.00016374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824043,0.00109057,0.01525891,0.0001609187,0.000527616,0.0003090444,0.00007990348,0.000009007078,0.000159753],"genre_scores_gemma":[0.9981444,0.0001238106,0.0006523409,0.0005355502,0.0001446845,0.00001053799,0.0001697189,0.0000368202,0.0001821185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0166662,"threshold_uncertainty_score":0.6694039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007364896375458016,"score_gpt":0.2598517482554488,"score_spread":0.2524868518799908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}