{"id":"W1991133464","doi":"10.1007/s00253-003-1307-6","title":"Dissolved-oxygen-stat controlling two variables for methanol induction of rGuamerin in Pichia pastoris and its application to repeated fed-batch","year":2003,"lang":"en","type":"article","venue":"Applied Microbiology and Biotechnology","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"Biotechnology Research Institute","funders":"","keywords":"Pichia pastoris; Methanol; Fed-batch culture; Chemistry; Chromatography; Pichia; Fermentation; Biochemistry; Food science; Biology; Organic chemistry; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003268395,0.0001622953,0.0002742891,0.0001597528,0.0000697013,0.000004967842,0.0001176125,0.0005443142,0.000002695383],"category_scores_gemma":[0.00008519529,0.0001516072,0.00002637238,0.0002022176,0.0001570141,0.000002132834,0.0001002924,0.0001562591,0.000001739608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001246778,"about_ca_system_score_gemma":0.00003570436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002318072,"about_ca_topic_score_gemma":0.00009020908,"domain_scores_codex":[0.9988211,0.00005340725,0.0002662838,0.0005227023,0.00002398269,0.0003124663],"domain_scores_gemma":[0.9995591,0.00003564959,0.00008745415,0.0002055643,0.0000644818,0.00004774571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003702617,0.00004914123,0.0003260668,0.00003201693,0.0000476768,2.981092e-7,0.00003134082,0.00003498338,0.9883782,0.004865025,0.00002911539,0.005835908],"study_design_scores_gemma":[0.001287316,0.0004317808,0.0001071327,0.000006908675,0.00001485607,0.00002528724,0.0001163177,0.00003851645,0.9840649,0.0005585237,0.01319,0.0001584752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859286,0.00141109,0.01125652,0.0003878161,0.00006014005,0.0008209805,0.00005434847,0.00001496698,0.00006554059],"genre_scores_gemma":[0.995657,0.0005015912,0.003345178,0.00009069862,0.00002881563,0.0002011168,0.000106796,0.00001550935,0.00005325596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01316088,"threshold_uncertainty_score":0.6182363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007754561260772848,"score_gpt":0.2502502541708619,"score_spread":0.242495692910089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}