{"id":"W1991173050","doi":"10.1155/2013/471346","title":"Conformation-Dependent High-Affinity Potent Ricin-Neutralizing Monoclonal Antibodies","year":2012,"lang":"en","type":"article","venue":"BioMed Research International","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Defence Research and Development Canada","funders":"Defence Research and Development Canada","keywords":"Ricin; Antidote; Monoclonal antibody; Epitope; Toxin; Neutralization; Antibody; Immunotoxin; Lethal dose; Chemistry; In vitro; Pharmacology; Molecular biology; Virology; Biochemistry; Biology; Toxicity; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0016038,0.0001632653,0.0001791299,0.0005345676,0.0004448751,0.00005775431,0.0005526663,0.0002050382,0.002558746],"category_scores_gemma":[0.0002726395,0.0001385251,0.00008995801,0.0001864625,0.0002734272,0.000471548,0.0003456766,0.0005607041,0.002994393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002020142,"about_ca_system_score_gemma":0.00008162692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003626975,"about_ca_topic_score_gemma":0.000009947993,"domain_scores_codex":[0.9980274,0.0002744647,0.0003738491,0.0002208246,0.0003150231,0.0007883655],"domain_scores_gemma":[0.9989926,0.0001975258,0.000130321,0.0002424452,0.000362859,0.00007419809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001881754,0.0005147826,0.003775555,0.00001652749,0.000392587,0.00000546215,0.0007899471,0.000004316126,0.9072181,0.05544936,0.02228749,0.009357676],"study_design_scores_gemma":[0.002104739,0.0002146335,0.1021068,0.00005418202,0.0000155633,0.0001216854,0.001354546,0.00003894398,0.6515306,0.001204102,0.240886,0.0003683001],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753422,0.00184259,0.0006048812,0.002022894,0.00992385,0.0004062246,0.0002828868,0.0001125228,0.009461921],"genre_scores_gemma":[0.9918478,0.0002933881,0.0005669228,0.0001132208,0.000362563,0.00004695318,0.0004622269,0.0000163878,0.006290541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2556875,"threshold_uncertainty_score":0.9983531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07258941000327009,"score_gpt":0.355264655140744,"score_spread":0.2826752451374739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}