{"id":"W1991190820","doi":"10.1159/000282068","title":"Cytochrome P450 2D6 as a Model Antigen","year":2010,"lang":"en","type":"article","venue":"Digestive Diseases","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Deutsche Forschungsgemeinschaft; Alberta Innovates - Health Solutions","keywords":"Autoimmunity; Immunology; Molecular mimicry; Epitope; Genetically modified mouse; CYP2D6; Autoimmune hepatitis; Medicine; Antibody; Hepatitis; Transgene; Biology; Virology; Cytochrome P450; Enzyme; Genetics; Gene; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002279372,0.0004833604,0.00034116,0.0004573968,0.0002145561,0.0004031478,0.000237404,0.0005844037,0.00205825],"category_scores_gemma":[0.00008824728,0.0001201555,0.0003390345,0.0003001392,0.0001951437,0.0002917756,0.0002284078,0.0009129455,0.0007669543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002823914,"about_ca_system_score_gemma":0.0001337363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002587839,"about_ca_topic_score_gemma":0.0002387879,"domain_scores_codex":[0.9997821,0.00005714395,0.00001278211,0.00005536199,0.00004991147,0.0000426295],"domain_scores_gemma":[0.9999299,0.00001132848,0.00001063299,0.00001166792,0.00000893671,0.0000276034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003948433,0.0002926551,0.0007517001,0.0001826575,0.00001692856,0.0002839038,0.00002224237,0.0002740921,0.9923154,0.0009862855,0.0004334668,0.004045726],"study_design_scores_gemma":[0.0001630145,0.004610631,0.004162078,0.00003302974,0.0000914064,0.002574465,0.00005789801,0.00372849,0.939705,0.0007077226,0.04414709,0.00001919314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.951928,0.01600169,0.02198762,0.0006376053,0.0005137055,0.0003233475,0.001241796,0.0002255592,0.007140749],"genre_scores_gemma":[0.9757341,0.007259026,0.008746956,0.0001778294,0.0001178955,0.0001860631,0.001374232,0.00002957904,0.006374394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00205825,"threshold_uncertainty_score":0.006885469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01076743974406765,"score_gpt":0.287481080238509,"score_spread":0.2767136404944414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}