{"id":"W1991229285","doi":"10.1021/bi201661g","title":"Ionic Residues of Human Serum Transferrin Affect Binding to the Transferrin Receptor and Iron Release","year":2011,"lang":"en","type":"article","venue":"Biochemistry","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute","keywords":"Chemistry; Transferrin receptor; Transferrin; Endosome; Biochemistry; Internalization; Mutant; Biophysics; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001797577,0.0001470906,0.0002109284,0.00004301164,0.00008342344,0.000006341781,0.0001153184,0.0001073726,0.0003328633],"category_scores_gemma":[0.00004073697,0.0001079731,0.00007814162,0.0001216164,0.0001052611,0.00002453733,0.00001775665,0.0001340474,0.00001346448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001397617,"about_ca_system_score_gemma":0.00004634272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001279369,"about_ca_topic_score_gemma":0.00002876062,"domain_scores_codex":[0.9991674,0.00002880183,0.0001950408,0.0002454474,0.0001563974,0.0002069472],"domain_scores_gemma":[0.9994617,0.00001691522,0.00002458114,0.0003232253,0.00002357488,0.0001500518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002482948,0.0001066372,0.007467869,0.0005550066,0.00001420742,0.00000435566,0.001435436,1.875661e-7,0.9864066,0.0001015545,0.001319951,0.002339928],"study_design_scores_gemma":[0.001006118,0.0001933222,0.03436798,0.0001230443,0.0001048282,0.000008871767,0.0008007246,7.592282e-7,0.9628593,0.00001461908,0.0003848892,0.0001355141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994401,0.0009453965,0.0000178492,0.0004932639,0.00005105275,0.0002728837,0.00003743188,0.00003417528,0.003746955],"genre_scores_gemma":[0.9981775,0.0001318103,0.0001655332,0.0001141262,0.00008727168,0.00001677582,0.00002025322,0.00002061891,0.001266124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02690011,"threshold_uncertainty_score":0.4403017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02112767475567771,"score_gpt":0.2590842995614998,"score_spread":0.2379566248058221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}