{"id":"W1991231915","doi":"10.1021/ci100479z","title":"Structural Chemistry of the Histone Methyltransferases Cofactor Binding Site","year":2011,"lang":"en","type":"article","venue":"Journal of Chemical Information and Modeling","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto; University Health Network; University of New Brunswick; Université de Sherbrooke; Structural Genomics Consortium","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Knut och Alice Wallenbergs Stiftelse; Stiftelsen för Strategisk Forskning; Genome Canada","keywords":"Methyltransferase; Cofactor; Binding site; Histone; Biochemistry; Chemistry; Effector; Chromatin; Biology; Computational biology; Enzyme; Methylation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001140664,0.0002542007,0.0002329264,0.00008281181,0.000230199,0.0002603855,0.0003759719,0.0002460744,0.001021102],"category_scores_gemma":[0.0001481527,0.0001765535,0.0001417602,0.0001518366,0.0002049987,0.000227509,0.0001587327,0.0005196064,0.0002990926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005020364,"about_ca_system_score_gemma":0.0004838214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002137454,"about_ca_topic_score_gemma":0.002354212,"domain_scores_codex":[0.9999501,0.000008385813,0.000001911411,0.00001083519,0.00001731277,0.00001154668],"domain_scores_gemma":[0.9999788,0.000005720363,0.000004669047,0.000002958899,0.000004083756,0.000003813601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002444753,0.00006554811,0.001369736,0.0003424157,0.00003368398,0.0003876747,0.0001131505,0.05432164,0.8979604,0.02253893,0.0006623095,0.02195993],"study_design_scores_gemma":[0.0001037066,0.000953397,0.004252967,0.00004108334,0.00008954158,0.0008611364,0.0001885001,0.09820832,0.8420636,0.01582007,0.03737438,0.00004329456],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9549142,0.006297005,0.02753347,0.0005255209,0.00003170799,0.00005478999,0.0004115593,0.0002138956,0.01001776],"genre_scores_gemma":[0.984956,0.003417871,0.009303145,0.00007148839,0.00000767163,0.00002142589,0.0002860782,0.00001908512,0.001917239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002137454,"threshold_uncertainty_score":0.004250109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02118520355683755,"score_gpt":0.2516043293345788,"score_spread":0.2304191257777413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}