{"id":"W1991231915","doi":"10.1021/ci100479z","title":"Structural Chemistry of the Histone Methyltransferases Cofactor Binding Site","year":2011,"lang":"en","type":"article","venue":"Journal of Chemical Information and Modeling","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto; University Health Network; University of New Brunswick; Université de Sherbrooke; Structural Genomics Consortium","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Knut och Alice Wallenbergs Stiftelse; Stiftelsen för Strategisk Forskning; Genome Canada","keywords":"Methyltransferase; Cofactor; Binding site; Histone; Biochemistry; Chemistry; Effector; Chromatin; Biology; Computational biology; Enzyme; Methylation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009397204,0.00006289045,0.00009503397,0.00002214071,0.00002405848,0.000007350974,0.00007479647,0.00008959937,0.00002140003],"category_scores_gemma":[0.00004570457,0.00004507482,0.00007846953,0.00004109213,0.00003757313,0.00003049049,0.0000242411,0.0000944963,2.941783e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001814633,"about_ca_system_score_gemma":0.00004832702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006241745,"about_ca_topic_score_gemma":3.151974e-7,"domain_scores_codex":[0.9994077,0.000007537092,0.0003673164,0.00003733139,0.0001157073,0.00006438845],"domain_scores_gemma":[0.9995041,0.000003763512,0.0002242972,0.00007271949,0.0001541838,0.00004089103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008496556,0.000003786337,0.0001036973,0.00002736938,0.00002317947,3.589542e-8,0.0003054969,0.001356735,0.9967782,0.000003536732,0.00004778847,0.001265168],"study_design_scores_gemma":[0.0003692217,0.00002084469,0.0000538348,0.00003207576,0.00002636244,0.00004051555,0.00006253438,0.01153609,0.9874859,0.00002823083,0.0002863645,0.00005801983],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951716,0.0002792613,0.00423138,0.00003434861,0.00007800424,0.00003499391,0.000008334338,0.000001669302,0.0001603764],"genre_scores_gemma":[0.9991751,0.00008515455,0.0006230555,0.00003120208,0.00005589781,4.019286e-7,0.00001551171,0.000003445417,0.00001018108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01017935,"threshold_uncertainty_score":0.1838098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02118520355683755,"score_gpt":0.2516043293345788,"score_spread":0.2304191257777413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}