{"id":"W1991231925","doi":"10.1016/j.neuron.2004.11.026","title":"BAG5 Inhibits Parkin and Enhances Dopaminergic Neuron Degeneration","year":2004,"lang":"en","type":"article","venue":"Neuron","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":200,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; University Health Network; University of Toronto; Montreal Neurological Institute and Hospital; University of Ottawa; Canada Research Chairs; Toronto Western Hospital","funders":"Canadian Institutes of Health Research; Parkinson Society Canada; Michael J. Fox Foundation for Parkinson's Research","keywords":"Parkin; Neurodegeneration; Ubiquitin ligase; Dopaminergic; Ubiquitin; Parkinson's disease; Proteasome; Cell biology; Biology; Hsp70; Neuroscience; Protein aggregation; Dopamine; Genetics; Heat shock protein; Disease; Gene; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002995875,0.0007052459,0.0005544595,0.000730947,0.000410524,0.0007237983,0.0006166439,0.0007088623,0.003347207],"category_scores_gemma":[0.0002266018,0.0003529154,0.0005665754,0.0003898669,0.0009729972,0.0006811448,0.0006115474,0.001657188,0.0008309088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007916522,"about_ca_system_score_gemma":0.0005393686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001438485,"about_ca_topic_score_gemma":0.002637559,"domain_scores_codex":[0.9995373,0.00008385035,0.00005547924,0.00006993977,0.00008243811,0.0001708459],"domain_scores_gemma":[0.9996023,0.00005498176,0.00008070511,0.00005400745,0.0000169,0.0001912165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001564824,0.0003511889,0.0004001914,0.00009431497,0.00005089134,0.0001703323,0.00004014967,0.0002935971,0.9933075,0.0006486078,0.0003719333,0.002706489],"study_design_scores_gemma":[0.0001139849,0.001013064,0.002518022,0.000008183833,0.00004056702,0.0002895946,0.00007065197,0.0009121138,0.9923548,0.0001469326,0.002519354,0.00001273285],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929386,0.001706454,0.001832558,0.0004113461,0.0002172227,0.00003525828,0.0007745892,0.0004010497,0.001682899],"genre_scores_gemma":[0.9940203,0.0004891404,0.00125667,0.0001097904,0.00003104335,0.00003367061,0.0008065528,0.0000563245,0.003196454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003347207,"threshold_uncertainty_score":0.01119757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0126034512407406,"score_gpt":0.2647935171752803,"score_spread":0.2521900659345397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}