{"id":"W1991269764","doi":"10.1093/oxfordjournals.molbev.a026368","title":"Evolution of the Eukaryotic Translation Termination System: Origins of Release Factors","year":2000,"lang":"en","type":"article","venue":"Molecular Biology and Evolution","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Canadian Institute for Advanced Research","funders":"Japan Society for the Promotion of Science; Medical Research Council; Burroughs Wellcome Fund","keywords":"Biology; Giardia lamblia; Release factor; Genetics; Stop codon; Gene; Eukaryotic translation; Phylogenetic tree; Elongation factor; Translation (biology); Transfer RNA; Messenger RNA; RNA; Ribosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000163691,0.0001040403,0.0001266476,0.00004290962,0.00007505927,0.000002370107,0.00009803914,0.0002148607,0.00001072864],"category_scores_gemma":[0.00003209728,0.00007884551,0.00008685793,0.0001015959,0.0001259053,0.000005176684,0.00001536549,0.00004353369,0.000001301729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004604442,"about_ca_system_score_gemma":0.00004401898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001357469,"about_ca_topic_score_gemma":0.00001124513,"domain_scores_codex":[0.9991872,0.0002113147,0.0002176073,0.0001966321,0.00007156014,0.0001157292],"domain_scores_gemma":[0.9995812,0.000009912131,0.0001155464,0.0002173757,0.00005026702,0.00002570762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006789721,0.00002426956,0.01268638,0.00004690166,0.00002157153,1.781004e-7,0.00002560936,0.0001114409,0.9742058,0.009554677,0.000003427454,0.003251829],"study_design_scores_gemma":[0.0003660606,0.000279467,0.07892217,0.00005509716,0.00006791828,0.00001221866,0.00007184767,0.0005098872,0.9177191,0.001531447,0.0003357721,0.0001289883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9698743,0.001281065,0.02819734,0.00003444692,0.00009309455,0.0002179682,0.00002102541,0.000007586419,0.0002731369],"genre_scores_gemma":[0.9995339,0.00003960696,0.0002924023,0.000007288021,0.0000265982,0.000009355398,0.00004090496,0.000007894121,0.00004208352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0662358,"threshold_uncertainty_score":0.3215227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006133416903289549,"score_gpt":0.2244766641457003,"score_spread":0.2183432472424108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}