{"id":"W1991294857","doi":"10.1021/ac035396m","title":"A Mammalian Genetic System To Screen for Small Molecules Capable of Disrupting Protein−Protein Interactions","year":2004,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Biotechnology Research Institute","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Two-hybrid screening; Repressor; Protein–protein interaction; Protein kinase domain; Kinase; Suppressor; Inducer; Small molecule; Cell biology; Doxycycline; Protein kinase A; Epidermal growth factor receptor; Gene; Receptor; Gene expression; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007377927,0.0009897462,0.001164989,0.001212255,0.0004282884,0.0006485305,0.001041851,0.0008249953,0.001756613],"category_scores_gemma":[0.0002775209,0.0005773704,0.0006726515,0.000657864,0.0004498053,0.000361182,0.0005479953,0.00172457,0.00165639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000508119,"about_ca_system_score_gemma":0.0003725626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005096571,"about_ca_topic_score_gemma":0.00124578,"domain_scores_codex":[0.9993332,0.0001484114,0.00007997402,0.0001148688,0.0002620895,0.00006150526],"domain_scores_gemma":[0.9997711,0.00006419767,0.00004472672,0.00004758633,0.00002872727,0.00004372372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003094841,0.0000373671,0.00005546645,0.00004405919,0.00001312309,0.00003350305,0.000007092113,0.00006684002,0.9971632,0.0002907884,0.000175843,0.00208176],"study_design_scores_gemma":[0.0000481081,0.0005552286,0.0008818287,0.000007379628,0.00006438969,0.000563997,0.000008067595,0.001970557,0.9774654,0.0001516446,0.01826432,0.00001908217],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2933027,0.0118478,0.6666214,0.00112154,0.0005933236,0.002254855,0.006908604,0.007619036,0.009730742],"genre_scores_gemma":[0.4947689,0.009271631,0.4608909,0.0007189585,0.0001483963,0.002759677,0.01530057,0.0005404603,0.01560069],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001756613,"threshold_uncertainty_score":0.005876422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01228405976089207,"score_gpt":0.2691643842597792,"score_spread":0.2568803244988871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}