{"id":"W1991295852","doi":"10.1038/nchembio.107","title":"Biomimetic synthesis of the IDO inhibitors exiguamine A and B","year":2008,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Natural product; Chemistry; Enzyme; Computational biology; Total synthesis; Biosynthesis; Chess endgame; Biochemistry; Combinatorial chemistry; Stereochemistry; Biology; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005674183,0.0001694006,0.0003183563,0.00002120878,0.00005123577,0.000002996009,0.0002966092,0.0007535445,0.0002681105],"category_scores_gemma":[0.001064718,0.000102506,0.0001458985,0.0001489448,0.0006760379,0.00001526607,0.000197475,0.0005014723,0.000003810131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002613659,"about_ca_system_score_gemma":0.00002033428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001124947,"about_ca_topic_score_gemma":4.804256e-7,"domain_scores_codex":[0.999079,0.00001717012,0.0002596505,0.0003116272,0.0001033547,0.000229218],"domain_scores_gemma":[0.9989172,0.0005597438,0.0001030286,0.0003032486,0.00003808299,0.00007868849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002403697,0.00005895579,0.006773944,0.00004422569,0.00002672129,0.000001406635,0.00001656364,9.695599e-9,0.9877198,0.0002094882,0.0005539045,0.004570992],"study_design_scores_gemma":[0.0001794422,0.000005068735,0.000320054,0.00004395216,0.0000244216,0.00004507711,0.000009507386,0.000004255511,0.9911112,0.000498374,0.007631206,0.0001274655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928154,0.001841019,5.789756e-7,0.0006844242,0.00006528438,0.00003383576,0.0000354473,0.00003021273,0.004493829],"genre_scores_gemma":[0.9992597,0.0001142761,0.000153911,0.0001372178,0.0001991903,0.00001089054,0.000007150346,0.00001361535,0.000104051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007077301,"threshold_uncertainty_score":0.5812026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006017165212131595,"score_gpt":0.2154666682767967,"score_spread":0.2094495030646651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}