{"id":"W1991297352","doi":"10.1002/prot.10209","title":"Crystal structure of MTH169, a crucial component of phosphoribosylformylglycinamidine synthetase","year":2002,"lang":"en","type":"article","venue":"Proteins Structure Function and Bioinformatics","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto","funders":"National Institute of General Medical Sciences","keywords":"Operon; Bacillus subtilis; Glutamine synthetase; Biology; Biochemistry; Glutamine amidotransferase; Adenylylation; Enzyme; Protein subunit; Archaea; Gene; Escherichia coli; Amino acid; Glutamine; Genetics; Bacteria; Biosynthesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003113956,0.0006801051,0.0007284759,0.0002846135,0.001111468,0.001092521,0.000846456,0.0009498826,0.0027125],"category_scores_gemma":[0.000580058,0.0003293881,0.0002899349,0.0004112751,0.0002877728,0.0004705559,0.0004019335,0.001681195,0.001083489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001318229,"about_ca_system_score_gemma":0.00162785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005536805,"about_ca_topic_score_gemma":0.007559652,"domain_scores_codex":[0.9998092,0.0000138732,0.000009633825,0.00003247998,0.00009944694,0.00003544379],"domain_scores_gemma":[0.9998052,0.00002488298,0.00002732397,0.000004591315,0.00003307178,0.0001050445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00217164,0.0007476677,0.005742939,0.001470499,0.0002300628,0.005003822,0.000562229,0.006187073,0.9044784,0.00775876,0.03504404,0.03060278],"study_design_scores_gemma":[0.003293303,0.002962869,0.04671463,0.0004903061,0.0005595676,0.009160294,0.002273234,0.05791275,0.4282796,0.00477098,0.4431814,0.0004010262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9212002,0.03197478,0.007610366,0.002439392,0.002334029,0.0004125946,0.01128617,0.0008424646,0.0219001],"genre_scores_gemma":[0.9171191,0.01170323,0.02138709,0.0003936203,0.000332506,0.0002239735,0.0346199,0.0002289578,0.01399163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005536805,"threshold_uncertainty_score":0.01100916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008066023548243697,"score_gpt":0.2093584089457262,"score_spread":0.2012923853974825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}