{"id":"W1991297352","doi":"10.1002/prot.10209","title":"Crystal structure of MTH169, a crucial component of phosphoribosylformylglycinamidine synthetase","year":2002,"lang":"en","type":"article","venue":"Proteins Structure Function and Bioinformatics","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto","funders":"National Institute of General Medical Sciences","keywords":"Operon; Bacillus subtilis; Glutamine synthetase; Biology; Biochemistry; Glutamine amidotransferase; Adenylylation; Enzyme; Protein subunit; Archaea; Gene; Escherichia coli; Amino acid; Glutamine; Genetics; Bacteria; Biosynthesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005528125,0.0001857348,0.0002315777,0.00007332012,0.00006815806,0.00001580453,0.000130822,0.000224829,0.0002050971],"category_scores_gemma":[0.00007117584,0.0001421732,0.00009061596,0.0001412489,0.0001928447,0.00001071282,0.0001376894,0.0001530453,9.293753e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008483144,"about_ca_system_score_gemma":0.00002265395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001458692,"about_ca_topic_score_gemma":0.00000919932,"domain_scores_codex":[0.9989295,0.00002270487,0.0003987449,0.0001687563,0.0002713522,0.0002089602],"domain_scores_gemma":[0.9992809,0.000005870174,0.0002001246,0.000259982,0.0001475823,0.0001055098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002414183,0.00004802021,0.0002144368,0.0003317558,0.00006928172,3.713702e-7,0.00007945941,0.00001083094,0.989561,0.0002239158,0.0003445686,0.008875004],"study_design_scores_gemma":[0.0008781027,0.0007554576,0.0004881905,0.00003737751,0.0000365745,0.00003709072,0.00009206741,0.001480629,0.9914212,0.0002826192,0.004301933,0.0001888205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927503,0.0007909266,0.005082135,0.00006976946,0.0001103483,0.0004628877,0.0003857094,0.00001055898,0.0003372893],"genre_scores_gemma":[0.994945,0.0001279205,0.004510681,0.00006909519,0.00007865467,0.000003819681,0.0001871405,0.0000123524,0.00006527341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008686184,"threshold_uncertainty_score":0.5797653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008066023548243697,"score_gpt":0.2093584089457262,"score_spread":0.2012923853974825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}