{"id":"W1991330040","doi":"10.1074/jbc.m605959200","title":"The Ubiquitin Ligase Itch Is Auto-ubiquitylated in Vivo and in Vitro but Is Protected from Degradation by Interacting with the Deubiquitylating Enzyme FAM/USP9X","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital; Université de Montréal","funders":"","keywords":"Lactacystin; Ubiquitin ligase; Ubiquitin; Proteasome; Endosome; Biology; Cell biology; Endocytic cycle; Deubiquitinating enzyme; Molecular biology; Intracellular; Endocytosis; Biochemistry; Proteasome inhibitor; Cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006823037,0.0002404043,0.0002721642,0.00002410693,0.0001625694,0.0001024198,0.0003261868,0.000329278,0.00004034548],"category_scores_gemma":[0.0003525003,0.0001319105,0.00008310415,0.000168167,0.0001654877,0.00001578014,0.0001456332,0.0006705574,6.546704e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005041172,"about_ca_system_score_gemma":0.00007780836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000160478,"about_ca_topic_score_gemma":0.00004447798,"domain_scores_codex":[0.9983837,0.0001655729,0.0005960991,0.0003201203,0.0001922281,0.0003422758],"domain_scores_gemma":[0.9987948,0.0002513799,0.0005535535,0.0002018841,0.0001257834,0.00007261121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007611382,0.00006940882,0.003411117,0.00001385881,0.00002797822,0.00001777746,0.00008075556,0.000006857585,0.9935343,6.452747e-7,0.0006360608,0.001440163],"study_design_scores_gemma":[0.0008374315,0.0001322661,0.0009128056,0.00009947454,0.00001144548,0.00008117788,0.0004872378,0.000302949,0.9939513,0.00009575437,0.002900805,0.0001873587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963448,0.00133402,0.0001455779,0.001598799,0.00002840303,0.0002184041,0.00006756047,0.000008909399,0.0002534962],"genre_scores_gemma":[0.9985831,0.0001453975,0.0004381227,0.0003346863,0.0002272254,0.00002371191,0.00004355717,0.00001515879,0.0001890332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002498312,"threshold_uncertainty_score":0.5379153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01178794003619075,"score_gpt":0.2313309750418044,"score_spread":0.2195430350056136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}