{"id":"W1991330040","doi":"10.1074/jbc.m605959200","title":"The Ubiquitin Ligase Itch Is Auto-ubiquitylated in Vivo and in Vitro but Is Protected from Degradation by Interacting with the Deubiquitylating Enzyme FAM/USP9X","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital; Université de Montréal","funders":"","keywords":"Lactacystin; Ubiquitin ligase; Ubiquitin; Proteasome; Endosome; Biology; Cell biology; Endocytic cycle; Deubiquitinating enzyme; Molecular biology; Intracellular; Endocytosis; Biochemistry; Proteasome inhibitor; Cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001816788,0.0003633332,0.0004238504,0.0002868976,0.0002813251,0.0004907491,0.0001838826,0.000306499,0.001567844],"category_scores_gemma":[0.0001662157,0.0002211288,0.0005279852,0.0003236669,0.0002289546,0.0002689907,0.0003004439,0.0003930366,0.0008194591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006761992,"about_ca_system_score_gemma":0.0002272004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009783659,"about_ca_topic_score_gemma":0.001223593,"domain_scores_codex":[0.9997894,0.00003007499,0.00001857934,0.00005728694,0.00004965958,0.00005494744],"domain_scores_gemma":[0.9998711,0.00001877455,0.00003484975,0.00002592356,0.00001781016,0.00003154063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001000596,0.00001098359,0.000628809,0.00005028139,0.0000262098,0.0000868275,0.000007593186,0.00008060116,0.9973983,0.0001086387,0.00005120601,0.001450583],"study_design_scores_gemma":[0.000009927761,0.00007155525,0.007497718,0.000005301446,0.00001792136,0.0004064068,0.00001392453,0.0006821563,0.9881598,0.00005977103,0.003069174,0.000006387827],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821723,0.007699426,0.007620978,0.0001591585,0.00005658355,0.00001620012,0.0006468432,0.0001220988,0.001506473],"genre_scores_gemma":[0.9888517,0.002343898,0.002438514,0.00007762539,0.0000198221,0.00001634577,0.001988673,0.00003327181,0.004230159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001567844,"threshold_uncertainty_score":0.00524497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01178794003619075,"score_gpt":0.2313309750418044,"score_spread":0.2195430350056136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}