{"id":"W1991352945","doi":"10.1371/journal.ppat.1000522","title":"LEDGF/p75 Proteins with Alternative Chromatin Tethers Are Functional HIV-1 Cofactors","year":2009,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Center for Research Resources; National Institute of General Medical Sciences; Medical Research Council; National Cancer Institute; University of Texas at El Paso; National Institutes of Health; University of Alberta; Mayo Foundation for Medical Education and Research","keywords":"Integrase; Chromatin; Nucleosome; Chromatin remodeling; Histone; Cell biology; Biology; Chemistry; DNA; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001152054,0.0002663994,0.0001015226,0.0001359066,0.0001844202,0.0004249243,0.0002291219,0.0002472098,0.001464761],"category_scores_gemma":[0.0001902699,0.0000980259,0.0001904494,0.00009724218,0.0003301385,0.0002848127,0.0002670649,0.0005777935,0.0003580019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006514181,"about_ca_system_score_gemma":0.0002272524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00192107,"about_ca_topic_score_gemma":0.002899949,"domain_scores_codex":[0.9998649,0.0000130258,0.000005551512,0.00001747138,0.00005533781,0.00004363272],"domain_scores_gemma":[0.9999079,0.00001583152,0.00001553438,0.00001680657,0.000008570352,0.00003547275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003861025,0.00000765724,0.0001847716,0.00001284311,0.000003076228,0.00008254714,0.000009646906,0.0000519879,0.9978362,0.0002410372,0.00002892751,0.00150263],"study_design_scores_gemma":[0.00001260902,0.00006178663,0.00352359,0.000004931547,0.00001078579,0.0005025209,0.00003109474,0.0007783396,0.9905724,0.0001034375,0.004393523,0.000004947417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934918,0.001036419,0.003299013,0.00007858648,0.00001769371,0.00001113608,0.0001014119,0.0000714048,0.001892438],"genre_scores_gemma":[0.9951546,0.0002161631,0.002166248,0.0000295709,0.000004740322,0.00000670383,0.0001589127,0.00001007278,0.002252942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00192107,"threshold_uncertainty_score":0.004900098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02427866560508101,"score_gpt":0.2313692200717551,"score_spread":0.2070905544666741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}