{"id":"W1991352945","doi":"10.1371/journal.ppat.1000522","title":"LEDGF/p75 Proteins with Alternative Chromatin Tethers Are Functional HIV-1 Cofactors","year":2009,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Center for Research Resources; National Institute of General Medical Sciences; Medical Research Council; National Cancer Institute; University of Texas at El Paso; National Institutes of Health; University of Alberta; Mayo Foundation for Medical Education and Research","keywords":"Integrase; Chromatin; Nucleosome; Chromatin remodeling; Histone; Cell biology; Biology; Chemistry; DNA; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.00006459386,0.0001991354,0.0002258877,0.00009092121,0.00021383,0.00001605641,0.0001220965,0.0001081638,0.001831623],"category_scores_gemma":[0.00004909069,0.0001376331,0.00006942657,0.0001154373,0.0001427617,0.00006895211,0.0000223167,0.0002434667,0.003633364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009484244,"about_ca_system_score_gemma":0.00008678643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001475943,"about_ca_topic_score_gemma":0.00002186379,"domain_scores_codex":[0.9988904,0.0001395862,0.0001453589,0.0003149889,0.00009396259,0.0004156797],"domain_scores_gemma":[0.999463,0.00005869439,0.00009157715,0.0002318717,0.00009452664,0.00006033708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007319047,0.001848879,0.05228817,0.00002286204,0.001194478,0.000332704,0.001358912,0.00004474403,0.9315221,0.0002896673,0.005691216,0.004674383],"study_design_scores_gemma":[0.007761142,0.004075931,0.4604636,0.0002321728,0.0001993217,0.000195507,0.001465012,0.00002282507,0.5098792,0.0002995841,0.01463677,0.0007689566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935992,0.0003469544,0.000306776,0.0006616858,0.00007189287,0.0006376524,0.0006203068,0.0001134942,0.003641978],"genre_scores_gemma":[0.995821,0.00001542599,0.0002403174,0.0001168082,0.00004735092,0.00009261304,0.0004510978,0.00001599038,0.003199393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4216429,"threshold_uncertainty_score":0.9990808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02427866560508101,"score_gpt":0.2313692200717551,"score_spread":0.2070905544666741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}