{"id":"W1991375218","doi":"10.1016/j.bbrc.2006.07.101","title":"Gating defects of a novel Na+ channel mutant causing hypokalemic periodic paralysis","year":2006,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institut national de la recherche scientifique","keywords":"Missense mutation; Skeletal muscle; Hypokalemic periodic paralysis; Arginine; Gating; Mutant; Mutation; HEK 293 cells; Periodic paralysis; Transfection; Chemistry; Protein subunit; Depolarization; Molecular biology; Hypokalemia; Biophysics; Biology; Gene; Endocrinology; Biochemistry; Medicine; Paralysis; Amino acid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000142819,0.000917099,0.0005236414,0.0003693519,0.000426889,0.0002693864,0.0006164552,0.0009583923,0.001672085],"category_scores_gemma":[0.0006430066,0.0002012423,0.0004770538,0.0002178618,0.0006707982,0.00024214,0.0005244978,0.0006778709,0.0004153605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002587122,"about_ca_system_score_gemma":0.0002926089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001593723,"about_ca_topic_score_gemma":0.001215416,"domain_scores_codex":[0.999801,0.00003760971,0.0000392375,0.00004128373,0.00004444067,0.00003643193],"domain_scores_gemma":[0.9996257,0.0001016417,0.000095303,0.0000333332,0.00003026865,0.0001137027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005704335,0.0001514787,0.001333461,0.00009530955,0.00005642017,0.038812,0.0001619723,0.0005225791,0.953664,0.000636016,0.000296852,0.003699539],"study_design_scores_gemma":[0.0006466529,0.002655903,0.08490212,0.0001030193,0.0004564067,0.2948304,0.0005932781,0.0179131,0.5895133,0.001430539,0.0066905,0.0002648112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955568,0.000201938,0.002375494,0.0001831256,0.0001206567,0.00006146698,0.0003214229,0.0001037989,0.001075301],"genre_scores_gemma":[0.9980863,0.00008871737,0.0008137717,0.00007151642,0.00001932238,0.00001939482,0.0001636328,0.00003888744,0.0006984147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001672085,"threshold_uncertainty_score":0.005593717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06684580619178249,"score_gpt":0.3404473522905856,"score_spread":0.2736015460988031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}