{"id":"W1991382760","doi":"10.1159/000078104","title":"HERG K&lt;sup&gt;+&lt;/sup&gt; Channel Conductance Promotes H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt;-Induced Apoptosis in HEK293 Cells: Cellular Mechanisms","year":2004,"lang":"en","type":"article","venue":"Cellular Physiology and Biochemistry","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"","keywords":"hERG; DNA fragmentation; Transfection; Apoptosis; Molecular biology; HEK 293 cells; Chemistry; Cell biology; Potassium channel; Biology; Programmed cell death; Biochemistry; Biophysics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001654416,0.0003000626,0.0004506288,0.0001260297,0.0001082483,0.000364371,0.0002170201,0.0003832414,0.00144283],"category_scores_gemma":[0.0001748462,0.0001100805,0.0003872533,0.0001523248,0.0002577045,0.0005261021,0.0002432846,0.0007125071,0.0006302458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000383842,"about_ca_system_score_gemma":0.0001827811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003251121,"about_ca_topic_score_gemma":0.0003803312,"domain_scores_codex":[0.9998401,0.00002296995,0.00001156353,0.00002903663,0.00003938153,0.0000569508],"domain_scores_gemma":[0.999879,0.00002180667,0.00003810096,0.00001429299,0.00001791129,0.00002890866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001493024,0.00003313011,0.0000946317,0.00004946235,0.000004581384,0.00007144934,0.00002000641,0.00005429082,0.9983965,0.0001476902,0.0001084896,0.0008705198],"study_design_scores_gemma":[0.00005010362,0.0002298125,0.005066629,0.00001100055,0.00001642188,0.0005333424,0.00004323587,0.001377869,0.9893318,0.0002047135,0.003128059,0.000007009844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863737,0.003974571,0.005982509,0.0004479765,0.00008072765,0.00006714811,0.0005690124,0.0002874544,0.002216936],"genre_scores_gemma":[0.9947305,0.001266738,0.001264932,0.0001759341,0.00001637785,0.00003426809,0.0003600552,0.00004192708,0.002109188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00144283,"threshold_uncertainty_score":0.004826725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008582955658559153,"score_gpt":0.2083012078691069,"score_spread":0.1997182522105477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}