{"id":"W1991393632","doi":"10.1371/journal.pbio.0060193","title":"The Threat of Instability: Neurodegeneration Predicted by Protein Destabilization and Aggregation Propensity","year":2008,"lang":"en","type":"letter","venue":"PLoS Biology","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Biology; Neurodegeneration; Protein aggregation; Cell biology; Disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001043226,0.0002215304,0.0002399944,0.00002897264,0.0001647163,0.00001526198,0.0001753016,0.0008603164,0.000001906903],"category_scores_gemma":[0.0002952935,0.0001546938,0.00004762112,0.00006858322,0.0004377199,0.000004662657,0.0001202812,0.0003272579,3.010823e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001630155,"about_ca_system_score_gemma":0.0001044983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002660795,"about_ca_topic_score_gemma":0.00004875055,"domain_scores_codex":[0.9986008,0.0003030227,0.0003137679,0.0004714138,0.0001072818,0.0002036747],"domain_scores_gemma":[0.9990083,0.00002764236,0.0002693695,0.0004492152,0.0002211295,0.00002434018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001176717,0.00003270046,0.005032193,0.0001327916,0.00008038691,0.000002131734,0.00002855647,0.000003871437,0.9590857,0.00005437005,0.03209445,0.003335141],"study_design_scores_gemma":[0.0006324452,0.001180139,0.0009215816,0.00004760163,0.00008753111,0.00004753091,0.000005039274,0.0004780884,0.7815655,0.001361297,0.2131821,0.0004911106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9762421,0.001442357,0.00140119,0.01892431,0.0001103562,0.00144852,0.0003307647,0.00002100547,0.00007938775],"genre_scores_gemma":[0.954131,0.002916503,0.0006782526,0.02380216,0.001330516,0.0003440828,0.01620439,0.00008300522,0.0005100992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1810877,"threshold_uncertainty_score":0.6635548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0118757160840177,"score_gpt":0.2042983522798256,"score_spread":0.1924226361958079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}