{"id":"W1991393632","doi":"10.1371/journal.pbio.0060193","title":"The Threat of Instability: Neurodegeneration Predicted by Protein Destabilization and Aggregation Propensity","year":2008,"lang":"en","type":"letter","venue":"PLoS Biology","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Biology; Neurodegeneration; Protein aggregation; Cell biology; Disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002424262,0.0008618347,0.001305786,0.0006275013,0.001195329,0.001567239,0.001108517,0.01285161,0.002513634],"category_scores_gemma":[0.01128625,0.0005540304,0.0005676905,0.0003173656,0.002236672,0.001563492,0.0006986817,0.01531519,0.003336298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001376563,"about_ca_system_score_gemma":0.0004812246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004083609,"about_ca_topic_score_gemma":0.0006672401,"domain_scores_codex":[0.9987734,0.0004495095,0.0001521998,0.0001843624,0.0003241882,0.000116326],"domain_scores_gemma":[0.9946583,0.003778281,0.0002765035,0.0002075589,0.0006446193,0.0004348189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.002039747,0.000276481,0.005889889,0.0002925671,0.0001233848,0.009817372,0.0002654319,0.0006172804,0.01278646,0.01122463,0.8761585,0.08050822],"study_design_scores_gemma":[0.002668981,0.00187802,0.01851951,0.0003618483,0.0003298841,0.03684158,0.0007717155,0.01860099,0.03132403,0.08504427,0.8031115,0.0005476213],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01060997,0.005474987,0.004230597,0.9335722,0.04112038,0.00006543539,0.0002159736,0.0002795394,0.004431015],"genre_scores_gemma":[0.109604,0.007100923,0.007924505,0.7618822,0.09123289,0.0004843979,0.000270479,0.0001697483,0.02133085],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01285161,"threshold_uncertainty_score":0.01282084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0118757160840177,"score_gpt":0.2042983522798256,"score_spread":0.1924226361958079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}