{"id":"W1991395730","doi":"10.1158/1538-7445.am2011-1061","title":"Abstract 1061: Context dependent tumor suppressor activity of the ERK pathway explains its inverse correlation with malignancy in prostate neoplasms","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Notre-Dame; Université de Montréal","funders":"","keywords":"MAPK/ERK pathway; Carcinogenesis; Senescence; Protein kinase B; Kinase; Cell biology; PI3K/AKT/mTOR pathway; Cancer research; Biology; Signal transduction; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006029525,0.0001342636,0.0002666136,0.0001440393,0.00008918896,0.00001250918,0.0001714073,0.00005833372,0.0008431769],"category_scores_gemma":[0.00005021674,0.00008674119,0.00006443291,0.0003897827,0.0001360839,0.0001566014,0.00006437957,0.0005528484,0.00001646353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002867598,"about_ca_system_score_gemma":0.0007698775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004093711,"about_ca_topic_score_gemma":0.007679292,"domain_scores_codex":[0.9982538,0.0001149841,0.0002072497,0.000310353,0.0007130776,0.0004005998],"domain_scores_gemma":[0.9990113,0.00005845954,0.0001089889,0.0004145939,0.0002892215,0.0001173844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01058683,0.0009253186,0.03212766,0.0006174895,0.0002010939,0.0004044522,0.01743883,0.0001602235,0.9096583,0.001920732,0.0004044598,0.02555461],"study_design_scores_gemma":[0.003362369,0.0005549197,0.1002315,0.0006486977,0.00001407733,0.00001574902,0.001002735,0.0001233828,0.8932693,0.0001941334,0.0004648141,0.0001183468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962478,0.0004171289,0.00002619022,0.0002381323,0.0001795619,0.001448252,0.00006130474,0.00001411108,0.001367565],"genre_scores_gemma":[0.9983296,0.0001479546,0.00002320502,0.00007197324,0.00004536318,0.0003776104,0.000002718714,0.00003076811,0.0009707613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06810381,"threshold_uncertainty_score":0.9232195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09502152367898448,"score_gpt":0.3352708240771181,"score_spread":0.2402493003981336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}