{"id":"W1991395730","doi":"10.1158/1538-7445.am2011-1061","title":"Abstract 1061: Context dependent tumor suppressor activity of the ERK pathway explains its inverse correlation with malignancy in prostate neoplasms","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Notre-Dame; Université de Montréal","funders":"","keywords":"MAPK/ERK pathway; Carcinogenesis; Senescence; Protein kinase B; Kinase; Cell biology; PI3K/AKT/mTOR pathway; Cancer research; Biology; Signal transduction; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001284729,0.0002013974,0.0001801395,0.0006409974,0.0001369616,0.0002549794,0.0001688466,0.0001864194,0.004052417],"category_scores_gemma":[0.0003081306,0.0001448573,0.000159396,0.0002889429,0.0002320362,0.0001273183,0.0001712879,0.0004647851,0.0006800266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009784482,"about_ca_system_score_gemma":0.000104691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000127538,"about_ca_topic_score_gemma":0.0001198497,"domain_scores_codex":[0.9998873,0.00002320044,0.000007441589,0.00002800109,0.00003154878,0.00002242993],"domain_scores_gemma":[0.9996361,0.00007267923,0.0001254168,0.00003579535,0.00002844993,0.0001015698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002840407,0.0003190515,0.2574141,0.0002455759,0.0001322919,0.0023236,0.00007420366,0.0003738627,0.7192767,0.0006455669,0.0005517921,0.01580282],"study_design_scores_gemma":[0.00002331969,0.0006420375,0.8715901,0.00001272334,0.0001309635,0.01673975,0.00008099047,0.00153346,0.1054151,0.0005791367,0.003233762,0.00001885949],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9938012,0.002884489,0.0009287671,0.00007857168,0.00001813474,0.00001231071,0.0002829953,0.0001003896,0.001893308],"genre_scores_gemma":[0.9987364,0.0002980692,0.0001735223,0.00001111705,0.00001538765,0.000004591563,0.0001299275,0.000007899587,0.000623016],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.004052417,"threshold_uncertainty_score":0.01355672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09502152367898448,"score_gpt":0.3352708240771181,"score_spread":0.2402493003981336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}