{"id":"W1991398796","doi":"10.1016/s0957-4166(02)00792-9","title":"Lipase-catalyzed stereoselective resolution and desymmetrization of binaphthols","year":2003,"lang":"en","type":"article","venue":"Tetrahedron Asymmetry","topic":"Axial and Atropisomeric Chirality Synthesis","field":"Chemistry","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"Brock University","funders":"","keywords":"Desymmetrization; Pseudomonas fluorescens; Kinetic resolution; Vinyl acetate; Chemistry; Substrate (aquarium); Enantioselective synthesis; Lipase; Enantiomer; Stereoselectivity; Acetone; Pseudomonas; Organic chemistry; Catalysis; Enantiomeric excess; Stereochemistry; Enzyme; Biology; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002205379,0.0001979116,0.000316707,0.0001744647,0.00009834288,0.00002331679,0.0001142684,0.0001562469,0.0002848054],"category_scores_gemma":[0.0006723971,0.000190933,0.00009179198,0.000619597,0.0001413899,0.0001556761,0.0000345285,0.0001598242,0.00001440347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007228074,"about_ca_system_score_gemma":0.00004297621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008939807,"about_ca_topic_score_gemma":0.000006834086,"domain_scores_codex":[0.9987018,0.00006820044,0.0003639031,0.0003424416,0.0002525601,0.000271152],"domain_scores_gemma":[0.9991163,0.000214131,0.0002068265,0.0002865093,0.00007291722,0.0001033086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002776334,0.0008251227,0.1622691,0.0009290677,0.0003531561,0.00001406955,0.0007471141,0.00001300185,0.6561605,0.03627625,0.0004239054,0.141711],"study_design_scores_gemma":[0.001409525,0.0001006532,0.02347348,0.0001303577,0.0001210708,0.00003536579,0.0008620581,0.000245174,0.9656197,0.003215255,0.004259566,0.000527823],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9646428,0.000727196,0.002403922,0.00005011892,0.00007148251,0.00009510283,0.00003347128,0.00008750118,0.03188836],"genre_scores_gemma":[0.9967691,0.00008377991,0.002326587,0.00002315056,0.00005169254,0.000009394924,0.00002235078,0.00002580247,0.0006881699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3094591,"threshold_uncertainty_score":0.7786022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01224532450607152,"score_gpt":0.2250016604603933,"score_spread":0.2127563359543218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}