{"id":"W1991404956","doi":"10.1007/s00280-010-1342-9","title":"Preclinical anti-tumor activity of antibody-targeted chemotherapy with CMC-544 (inotuzumab ozogamicin), a CD22-specific immunoconjugate of calicheamicin, compared with non-targeted combination chemotherapy with CVP or CHOP","year":2010,"lang":"en","type":"article","venue":"Cancer Chemotherapy and Pharmacology","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Calicheamicin; Immunoconjugate; CD22; Chemotherapy; CHOP; Cancer research; Medicine; Monoclonal antibody; Antibody; Internal medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003562324,0.0006395759,0.0006201037,0.000465125,0.0001735714,0.0003778851,0.0005591222,0.0005195063,0.002995199],"category_scores_gemma":[0.0003694311,0.0003303161,0.0004306519,0.0004099431,0.000477225,0.0005468099,0.0001373804,0.001586986,0.0003562747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005663894,"about_ca_system_score_gemma":0.0007103294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001676048,"about_ca_topic_score_gemma":0.001526599,"domain_scores_codex":[0.9997968,0.00005614087,0.00001099874,0.00002824734,0.00002771496,0.00008013872],"domain_scores_gemma":[0.9996356,0.00009993933,0.00008288074,0.00003085995,0.00003072996,0.0001199349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.07173111,0.01668047,0.001072955,0.0002609033,0.0001643788,0.0001993357,0.00009417678,0.004734269,0.877831,0.0005541221,0.001245114,0.02543215],"study_design_scores_gemma":[0.005978985,0.1628957,0.005756411,0.00002050363,0.0004100105,0.0003828757,0.00006051463,0.005539795,0.8168367,0.0001955598,0.001896012,0.00002692577],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960268,0.001352552,0.000478018,0.00011291,0.00008285147,0.00008614377,0.0004757479,0.00007559118,0.001309393],"genre_scores_gemma":[0.9970462,0.0007580566,0.0003444574,0.00003142483,0.00004052428,0.00005915205,0.0006214757,0.00001515683,0.00108362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002995199,"threshold_uncertainty_score":0.0100199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01762662808946152,"score_gpt":0.3344375505906821,"score_spread":0.3168109225012206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}