{"id":"W1991404956","doi":"10.1007/s00280-010-1342-9","title":"Preclinical anti-tumor activity of antibody-targeted chemotherapy with CMC-544 (inotuzumab ozogamicin), a CD22-specific immunoconjugate of calicheamicin, compared with non-targeted combination chemotherapy with CVP or CHOP","year":2010,"lang":"en","type":"article","venue":"Cancer Chemotherapy and Pharmacology","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Calicheamicin; Immunoconjugate; CD22; Chemotherapy; CHOP; Cancer research; Medicine; Monoclonal antibody; Antibody; Internal medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002741101,0.0006787116,0.001743252,0.0002131739,0.0001464192,0.00002285101,0.0002362042,0.0002790659,0.001399169],"category_scores_gemma":[0.000005431643,0.0004315304,0.0001473446,0.0005728886,0.001027338,0.0001818361,0.00002312484,0.0005342378,0.000002112159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001844618,"about_ca_system_score_gemma":0.0007330073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006348733,"about_ca_topic_score_gemma":0.0001331677,"domain_scores_codex":[0.9973229,0.0001187565,0.0006823275,0.000851692,0.0004214747,0.0006028441],"domain_scores_gemma":[0.9976062,0.0002715019,0.0008134986,0.0005412048,0.0004986918,0.0002689108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.04719944,0.003857173,0.1128341,0.0003791729,0.002148697,0.00006304301,0.001341261,0.00001798096,0.821379,0.00001364006,0.0005749157,0.0101916],"study_design_scores_gemma":[0.05991343,0.004572905,0.2544332,0.000255125,0.0003431663,0.0001398958,0.00008264979,0.0006544868,0.6769153,0.000007965986,0.002282228,0.0003996558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936672,0.0009605626,0.0002344259,0.002188054,0.000255356,0.002373947,0.0001041469,0.00008145095,0.0001348016],"genre_scores_gemma":[0.9907351,0.005086237,0.001206445,0.002221798,0.0002027391,0.0002402873,0.00007970523,0.000126933,0.0001008158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1444638,"threshold_uncertainty_score":0.9998137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01762662808946152,"score_gpt":0.3344375505906821,"score_spread":0.3168109225012206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}