{"id":"W1991426846","doi":"10.1021/ac050761q","title":"Inhibitor Screening Using Immobilized Enzyme Reactor Chromatography/Mass Spectrometry","year":2005,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Microfluidic and Capillary Electrophoresis Applications","field":"Engineering","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Chemistry; Chromatography; Substrate (aquarium); Analyte; Elution; Mass spectrometry; Tandem mass spectrometry; Inosine; Monolithic HPLC column; Enzyme; High-performance liquid chromatography; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00008756196,0.000231499,0.0002665818,0.00006197731,0.00007033492,0.0000550272,0.0001973712,0.0001723761,0.0009167221],"category_scores_gemma":[0.00001994873,0.0002438211,0.0001857399,0.0005312841,0.00007548019,0.00008507764,0.00002632833,0.0003028098,0.00003824494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001261371,"about_ca_system_score_gemma":0.00002651296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004772145,"about_ca_topic_score_gemma":1.530786e-7,"domain_scores_codex":[0.998718,0.000007681529,0.0003301416,0.00029137,0.0002131386,0.0004396506],"domain_scores_gemma":[0.9992995,0.00004151838,0.00003329413,0.0003821125,0.00003631892,0.000207267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005617491,0.00002844361,0.0001230891,0.00004022474,0.0001121739,0.000003882202,0.000007979934,0.00008028431,0.9891983,0.00009556865,0.01014976,0.0001546284],"study_design_scores_gemma":[0.0002720576,0.00000716343,0.00006018239,0.0000234658,0.00007889237,0.00002838939,0.00003014373,0.02965747,0.933411,0.00005060307,0.03607221,0.0003084489],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9459835,0.01455702,0.0292231,0.00009703113,0.00002615834,0.0001096084,0.0000169278,0.0004401552,0.009546519],"genre_scores_gemma":[0.9946403,0.001642049,0.002834581,0.00004943737,0.0005894508,0.0000119642,0.00003231422,0.00005386274,0.000146062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05578738,"threshold_uncertainty_score":0.9999966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009824582468266518,"score_gpt":0.226071640897236,"score_spread":0.2162470584289695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}