{"id":"W1991426846","doi":"10.1021/ac050761q","title":"Inhibitor Screening Using Immobilized Enzyme Reactor Chromatography/Mass Spectrometry","year":2005,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Microfluidic and Capillary Electrophoresis Applications","field":"Engineering","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Chemistry; Chromatography; Substrate (aquarium); Analyte; Elution; Mass spectrometry; Tandem mass spectrometry; Inosine; Monolithic HPLC column; Enzyme; High-performance liquid chromatography; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001048012,0.001388655,0.001153615,0.0009827941,0.0003488586,0.001127049,0.001752037,0.001032828,0.000823048],"category_scores_gemma":[0.0008257751,0.0005543216,0.0006163116,0.0006161406,0.0004494354,0.0004477281,0.0004657611,0.001051101,0.001410477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008182088,"about_ca_system_score_gemma":0.0008008563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001143654,"about_ca_topic_score_gemma":0.002172929,"domain_scores_codex":[0.998655,0.0001926441,0.00009529021,0.0003109167,0.0006340065,0.0001122116],"domain_scores_gemma":[0.9994778,0.0001442973,0.0001012416,0.00006192135,0.0001494122,0.0000652649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006691169,0.00007351125,0.0002130968,0.00009159211,0.00002559351,0.00005953474,0.00000837613,0.0002199306,0.9899061,0.000149661,0.0001501249,0.009035572],"study_design_scores_gemma":[0.00002189598,0.0001672285,0.0004610479,0.000005990003,0.00003705868,0.0002534487,0.000003801353,0.005393508,0.990908,0.00006595904,0.002660644,0.00002142527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3084595,0.01917653,0.654285,0.0007184381,0.0003333374,0.001283863,0.002163852,0.008483798,0.005095816],"genre_scores_gemma":[0.3206921,0.007602018,0.6617081,0.0007205701,0.0001205614,0.0007287952,0.002284214,0.0001981095,0.0059456],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001752037,"threshold_uncertainty_score":0.005936563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009824582468266518,"score_gpt":0.226071640897236,"score_spread":0.2162470584289695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}