{"id":"W1991435125","doi":"10.1038/tpj.2009.64","title":"Alternative-splicing forms of the major phase II conjugating UGT1A gene negatively regulate glucuronidation in human carcinoma cell lines","year":2009,"lang":"en","type":"article","venue":"The Pharmacogenomics Journal","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Glucuronidation; Exon; Alternative splicing; Gene isoform; Gene knockdown; Biology; RNA splicing; Gene; Gene expression; Endogeny; Biochemistry; Cell biology; RNA; Molecular biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002294431,0.0003091664,0.0003089413,0.0003311678,0.0002402719,0.0005619882,0.0002072907,0.0002733336,0.002214],"category_scores_gemma":[0.0003971018,0.0002411728,0.0003630447,0.0003049591,0.0002993899,0.0001996092,0.0002213961,0.0006230198,0.0007847029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003915286,"about_ca_system_score_gemma":0.0002725924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001391579,"about_ca_topic_score_gemma":0.001444437,"domain_scores_codex":[0.9996926,0.00008561086,0.00003190124,0.00004899925,0.00009428671,0.00004660223],"domain_scores_gemma":[0.9995812,0.0001524821,0.00006504248,0.00009650767,0.00006963508,0.00003516014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001277893,0.00002615086,0.0007416168,0.00001270866,0.000007004853,0.00007905014,0.00003474544,0.00006189085,0.9976878,0.0002741966,0.00010425,0.0008428232],"study_design_scores_gemma":[0.00002305635,0.0002222053,0.01184256,0.000003728627,0.00002749434,0.0007648851,0.00009056288,0.00174543,0.9821851,0.0001423825,0.00294548,0.000007018733],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956769,0.0006840315,0.001823361,0.0001301018,0.00003722365,0.00001708173,0.0004328278,0.00006133607,0.001137047],"genre_scores_gemma":[0.9951932,0.0003794949,0.001199225,0.00004026066,0.00001350526,0.00001890432,0.001226426,0.00004701734,0.001881875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002214,"threshold_uncertainty_score":0.007406592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08082405094282673,"score_gpt":0.4104322238664293,"score_spread":0.3296081729236026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}