{"id":"W1991457939","doi":"10.1074/jbc.m114.584391","title":"γ-Interferon-inducible Lysosomal Thiol Reductase (GILT) Maintains Phagosomal Proteolysis in Alternatively Activated Macrophages","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Toxoplasma gondii Research Studies","field":"Immunology and Microbiology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Phagosome; Cathepsin; NADPH oxidase; Endosome; Cell biology; Biochemistry; Proteolysis; Chemistry; Lysosome; Cysteine protease; Cysteine; Phagolysosome; Biology; Intracellular; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008611081,0.0003078968,0.0007080688,0.000130496,0.0001311463,0.00002737703,0.0006538701,0.0004449958,0.0007847422],"category_scores_gemma":[0.001723218,0.0002054964,0.0002458356,0.0002435361,0.0005120544,0.0001272841,0.0002918158,0.001336812,0.00006486449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001865731,"about_ca_system_score_gemma":0.00009738035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001693065,"about_ca_topic_score_gemma":0.000002038566,"domain_scores_codex":[0.997664,0.00044436,0.0007426612,0.0003898362,0.0001176608,0.0006415151],"domain_scores_gemma":[0.9985282,0.0004177373,0.0005103931,0.0002459908,0.0002071261,0.00009053923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001157099,0.0003748463,0.005562596,0.00003390504,0.000298525,0.0001375331,0.0001256703,0.00001145964,0.9898993,0.0000298735,0.0005157735,0.001853354],"study_design_scores_gemma":[0.002173309,0.0007785113,0.006885809,0.0001019809,0.00002066623,0.0005124288,0.0004110232,0.000004613143,0.9865167,0.0003132321,0.00206075,0.0002210096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967175,0.0007644964,0.00005936247,0.0006818192,0.0001787618,0.0001685459,0.00002895965,0.00003153699,0.001369079],"genre_scores_gemma":[0.9984605,0.0001733089,0.0002671663,0.0000601317,0.0002020191,0.00002056233,0.0000188666,0.00001456444,0.0007828531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003382697,"threshold_uncertainty_score":0.8592377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02344253972508913,"score_gpt":0.2777267581965908,"score_spread":0.2542842184715017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}