{"id":"W1991457939","doi":"10.1074/jbc.m114.584391","title":"γ-Interferon-inducible Lysosomal Thiol Reductase (GILT) Maintains Phagosomal Proteolysis in Alternatively Activated Macrophages","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Toxoplasma gondii Research Studies","field":"Immunology and Microbiology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Phagosome; Cathepsin; NADPH oxidase; Endosome; Cell biology; Biochemistry; Proteolysis; Chemistry; Lysosome; Cysteine protease; Cysteine; Phagolysosome; Biology; Intracellular; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002282265,0.0001565135,0.0001796746,0.0001430492,0.00008373157,0.0001938692,0.0001172287,0.0001630225,0.0004301479],"category_scores_gemma":[0.0001552104,0.00007273175,0.0002031324,0.00007938982,0.0002014745,0.0001136532,0.0001784875,0.0002421273,0.0001995464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001683696,"about_ca_system_score_gemma":0.0001827327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002697396,"about_ca_topic_score_gemma":0.0003902778,"domain_scores_codex":[0.999866,0.00003658471,0.00001536173,0.00002340319,0.00002416447,0.00003442895],"domain_scores_gemma":[0.9998703,0.0000149803,0.00004434447,0.00002809482,0.00001870866,0.00002356247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001407411,0.000007620931,0.0003560973,0.00001434686,0.000002815453,0.00004870291,0.00001186757,0.00001128679,0.9989789,0.00002259121,0.000006227418,0.0003988085],"study_design_scores_gemma":[0.00001977489,0.0003706996,0.01139783,0.00000766991,0.00002251817,0.0004080487,0.00005939236,0.000347952,0.98627,0.00005896114,0.001033536,0.000003520645],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971035,0.0009770276,0.00136829,0.00006159148,0.00001118122,0.000008986347,0.00009648104,0.00002906139,0.000343918],"genre_scores_gemma":[0.9978892,0.0003306501,0.0009089931,0.00002196746,0.00000537676,0.00001055276,0.0001715076,0.000008880646,0.0006528937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004301479,"threshold_uncertainty_score":0.001438975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02344253972508913,"score_gpt":0.2777267581965908,"score_spread":0.2542842184715017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}