{"id":"W1991466774","doi":"10.1016/j.ydbio.2012.04.022","title":"Enhanced expression of VEGF-A in β cells increases endothelial cell number but impairs islet morphogenesis and β cell proliferation","year":2012,"lang":"en","type":"article","venue":"Developmental Biology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":85,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Sunnybrook Health Science Centre; Mount Sinai Hospital","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Eye Institute; Vanderbilt Diabetes Research and Training Center, Vanderbilt University Medical Center; National Cancer Institute; National Institutes of Health; Eli Lilly and Company; U.S. Department of Veterans Affairs","keywords":"Biology; Islet; Cell biology; Angiogenesis; Endocrinology; Vascular endothelial growth factor; Internal medicine; Vascular endothelial growth factor A; Cellular differentiation; Cell growth; Endothelial stem cell; Insulin; Cancer research; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001447129,0.0001324315,0.0002718625,0.00009223077,0.00002987365,0.000002947707,0.00003151365,0.0001235769,0.0004610956],"category_scores_gemma":[0.00003928113,0.0001066706,0.0000287187,0.0000899623,0.00006672325,0.00006374929,0.0000452416,0.00006169954,0.00007484353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005142815,"about_ca_system_score_gemma":0.0000757443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009891798,"about_ca_topic_score_gemma":0.000002206129,"domain_scores_codex":[0.9991673,0.00007311254,0.0002744274,0.0001717749,0.00007317687,0.0002401675],"domain_scores_gemma":[0.9996098,0.00009471782,0.0000841204,0.00007391378,0.00002792611,0.0001094983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001203707,0.0002020889,0.3154601,0.00005119985,0.000004830099,7.035001e-7,0.0003151583,1.227696e-7,0.6834307,0.00000356639,0.000139083,0.0002721321],"study_design_scores_gemma":[0.00167485,0.00009004649,0.04762892,0.00003303725,0.0000150478,0.00001210183,0.0004464024,0.000004333311,0.9496549,0.000008391834,0.0003267328,0.0001051868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948235,0.000208231,0.00007141574,0.00001180778,0.0001369579,0.0002560516,0.0000315663,0.00001875093,0.00444179],"genre_scores_gemma":[0.9957469,0.0000972109,0.00329756,0.0002118279,0.00007085499,0.00004345975,0.0001004199,0.00001058298,0.0004211446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2678312,"threshold_uncertainty_score":0.5048673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009753866773571512,"score_gpt":0.2349062657392189,"score_spread":0.2251523989656473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}