{"id":"W1991473393","doi":"10.1038/onc.2010.483","title":"Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo","year":2010,"lang":"en","type":"article","venue":"Oncogene","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":182,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Metformin; AMPK; Hyperinsulinemia; Biology; Endocrinology; Internal medicine; Insulin; Cancer research; Small interfering RNA; Insulin resistance; In vivo; Protein kinase A; Kinase; Transfection; Cell culture; Cell biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002419342,0.0002924443,0.0003604333,0.0008825631,0.0002557598,0.0005517882,0.0001847277,0.0003585718,0.00236192],"category_scores_gemma":[0.0002882575,0.0004897948,0.0002600671,0.0004454226,0.0004045193,0.0003913909,0.0002671818,0.0007467399,0.0005473165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006331831,"about_ca_system_score_gemma":0.0002716926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008672808,"about_ca_topic_score_gemma":0.001666154,"domain_scores_codex":[0.9997019,0.00007841034,0.00002493493,0.00004910721,0.00006024705,0.00008529246],"domain_scores_gemma":[0.9996718,0.00009756634,0.00009056025,0.00003432087,0.00002340059,0.00008236778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00147287,0.0000810963,0.001676348,0.0000147557,0.00001212692,0.00002579644,0.00001775859,0.00006423309,0.9957454,0.000119061,0.00004520375,0.0007253453],"study_design_scores_gemma":[0.00004294605,0.0004327093,0.02113053,0.000003086697,0.00003334272,0.0001892261,0.00004467889,0.000812576,0.9764039,0.00007966796,0.0008200167,0.00000745621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975392,0.0006473926,0.0006925699,0.00008614501,0.00001489467,0.000008933498,0.0003199094,0.00003816713,0.0006527908],"genre_scores_gemma":[0.9968441,0.0003322094,0.0006382567,0.00003949644,0.000005045978,0.00002566414,0.0005412571,0.00002976904,0.001544336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00236192,"threshold_uncertainty_score":0.00790143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004355787182678638,"score_gpt":0.2424465385760012,"score_spread":0.2380907513933225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}