{"id":"W1991482221","doi":"10.1016/j.euroneuro.2014.09.014","title":"Efficacy and safety of extended-release guanfacine hydrochloride in children and adolescents with attention-deficit/hyperactivity disorder: A randomized, controlled, Phase III trial","year":2014,"lang":"en","type":"article","venue":"European Neuropsychopharmacology","topic":"Attention Deficit Hyperactivity Disorder","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Centre of Excellence for Child and Youth Mental Health","funders":"Bristol-Myers Squibb","keywords":"Guanfacine; Attention deficit hyperactivity disorder; Randomized controlled trial; Medicine; Psychology; Anesthesia; Psychiatry; Internal medicine; Clonidine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00136513,0.0004770793,0.002128668,0.0004011874,0.0001061551,0.00002514102,0.0001331669,0.00007872112,0.00006107546],"category_scores_gemma":[0.0006970166,0.0003727232,0.0002219816,0.0003116347,0.000527075,0.0001812994,0.0001103713,0.0006680797,0.00001581863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002108896,"about_ca_system_score_gemma":0.0000412708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003908342,"about_ca_topic_score_gemma":0.000006617812,"domain_scores_codex":[0.99495,0.002325262,0.001107929,0.0008445613,0.0003437111,0.0004285429],"domain_scores_gemma":[0.9980186,0.0005873551,0.0006158119,0.0003887232,0.0001162272,0.0002732467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9273584,0.004105909,0.03875041,0.00006526155,0.0003360438,0.00008481928,0.00004572452,0.00005948827,0.02108459,0.00002808827,0.00001346994,0.00806784],"study_design_scores_gemma":[0.6931446,0.001366035,0.3031934,0.0001179914,0.0007139032,0.000254481,0.00002635332,0.0008996958,0.000003756775,0.000002288646,0.00005834689,0.0002191425],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919176,0.0003874639,0.0006064231,0.0005376991,0.000269187,0.005534569,0.00001222669,0.0001134046,0.0006214001],"genre_scores_gemma":[0.998235,0.0007519328,0.00004559584,0.0004229681,0.0001921129,0.00007411779,0.00002437544,0.0001242216,0.0001297037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.264443,"threshold_uncertainty_score":0.9998724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00873314071440073,"score_gpt":0.2938475706097243,"score_spread":0.2851144298953235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}