{"id":"W1991532241","doi":"10.1074/jbc.m110.141150","title":"Analysis of the Biogenesis of Heparan Sulfate Acetyl-CoA:α-Glucosaminide N-Acetyltransferase Provides Insights into the Mechanism Underlying Its Complete Deficiency in Mucopolysaccharidosis IIIC","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Institute for Research in Immunology and Cancer; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Canadian Institutes of Health Research","keywords":"Heparan sulfate; Biochemistry; Biogenesis; Biology; Sulfatase; Cell biology; Immunoprecipitation; Cytoplasm; Chemistry; Enzyme; Gene; Glycosaminoglycan","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006057303,0.0002968308,0.0001541237,0.0001797926,0.0001270598,0.0001749379,0.0001050896,0.0001672426,0.0004285913],"category_scores_gemma":[0.00007948997,0.00008281133,0.0001965946,0.0001205238,0.0001704898,0.0001382186,0.0001352039,0.0001964237,0.0002212739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004240483,"about_ca_system_score_gemma":0.0003397577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001134809,"about_ca_topic_score_gemma":0.0008061259,"domain_scores_codex":[0.9999593,0.000005463365,0.000005043072,0.00001181047,0.00000979582,0.000008547358],"domain_scores_gemma":[0.9999546,0.000005234796,0.00001129768,0.000004655382,0.000006912429,0.00001734021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000537698,0.000005680195,0.0008173235,0.00001477035,0.000002711297,0.0001193974,0.00000927051,0.00005452189,0.9978904,0.0001257969,0.00001132909,0.0008950086],"study_design_scores_gemma":[0.00001124946,0.000167252,0.03196977,0.000008138088,0.00002599199,0.00129299,0.00006453349,0.00206577,0.9615666,0.0002082158,0.002612785,0.000006597172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961288,0.001026658,0.002081418,0.0000559587,0.000006554735,0.000007334313,0.0001434391,0.00002320407,0.0005266719],"genre_scores_gemma":[0.9954981,0.0009900387,0.001865256,0.00002045398,0.000005093865,0.000007928369,0.0006724487,0.000008785501,0.0009319168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001134809,"threshold_uncertainty_score":0.003076673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05656014204830604,"score_gpt":0.3110675505763396,"score_spread":0.2545074085280335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}