{"id":"W1991554870","doi":"10.1016/j.leukres.2014.08.008","title":"Polymeric nanoparticle-mediated silencing of CD44 receptor in CD34+ acute myeloid leukemia cells","year":2014,"lang":"en","type":"article","venue":"Leukemia Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; BC Cancer Agency; Canadian Blood Services; University of Alberta","funders":"University of Alberta; Alberta Innovates; Alberta Innovates - Health Solutions; Canadian Blood Services","keywords":"CD44; Gene silencing; Myeloid leukemia; Cancer research; Stem cell; Leukemia; Jurkat cells; Chemistry; Biology; Cell biology; Cell; Immunology; Biochemistry; Immune system; T cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001383985,0.0001868773,0.0001761815,0.0001267743,0.0001439607,0.0002366569,0.0001740423,0.0002896785,0.0006480044],"category_scores_gemma":[0.00008699398,0.0001022061,0.0001748879,0.0001233729,0.0001374619,0.0001256084,0.0001111232,0.0003095749,0.0001701957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003178025,"about_ca_system_score_gemma":0.0001612039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008042162,"about_ca_topic_score_gemma":0.001003567,"domain_scores_codex":[0.9998648,0.00001915282,0.000009592646,0.00003360065,0.0000412559,0.00003166058],"domain_scores_gemma":[0.9999686,0.000009862174,0.000007150252,0.000004604143,0.000005489121,0.000004233921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003091645,0.00001319561,0.00003284965,0.0000150908,0.000002068829,0.00001899276,0.00001023786,0.00009378105,0.9986485,0.0001535373,0.00002934691,0.0009516441],"study_design_scores_gemma":[0.000009387394,0.0001043138,0.0004061506,0.000001171737,0.000009410206,0.00004988545,0.000005762854,0.001134831,0.9970818,0.00002117634,0.001174568,0.000001552168],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907323,0.0007119189,0.005939278,0.00009247294,0.00003823534,0.00003655807,0.00009548353,0.00008648128,0.00226721],"genre_scores_gemma":[0.9932953,0.0002897347,0.00312782,0.00003578844,0.000006860962,0.00003386508,0.0001069454,0.00001234042,0.003091487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008042162,"threshold_uncertainty_score":0.002305806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02026833954695722,"score_gpt":0.2966030288540788,"score_spread":0.2763346893071216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}