{"id":"W1991584076","doi":"10.1093/nar/gkn1046","title":"Structural and biochemical characterization of MepR, a multidrug binding transcription regulator of the Staphylococcus aureus multidrug efflux pump MepA","year":2009,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Lawrence Berkeley National Laboratory; Basic Energy Sciences; National Institute of Allergy and Infectious Diseases; Office of Science; National Institutes of Health; Hospital for Sick Children; Welch Foundation; Shriners Hospitals for Children; U.S. Department of Energy","keywords":"Biology; Repressor; Binding site; Plasma protein binding; Allosteric regulation; Transcription factor; Gene; Genetics; Biochemistry; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007467585,0.0002291286,0.0004934353,0.0002763247,0.0002047431,0.00003051945,0.0003398824,0.0002484898,0.00006299101],"category_scores_gemma":[0.0005014838,0.000167572,0.0001792132,0.0008630478,0.000715799,0.0001738376,0.0001006345,0.0006242429,0.000004554919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001634055,"about_ca_system_score_gemma":0.0001554152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004463428,"about_ca_topic_score_gemma":0.000004735554,"domain_scores_codex":[0.9971402,0.0002320147,0.0005911881,0.0004538404,0.001065451,0.0005173552],"domain_scores_gemma":[0.9983365,0.0001101354,0.0001999386,0.0006323537,0.0005417942,0.0001793023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006283484,0.000107926,0.01207398,0.0002374789,0.0000440461,0.000003767158,0.001079874,0.000001463155,0.9821082,0.0001860677,0.0001499677,0.003378894],"study_design_scores_gemma":[0.001301724,0.0001908004,0.3300176,0.0003198783,0.00003536067,0.000006089715,0.0002440133,0.001010526,0.6665235,0.00007525511,0.0001620462,0.0001131753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970533,0.0001023639,0.00004694902,0.001279015,0.00009223333,0.001146261,0.0001101137,0.00003472863,0.0001350143],"genre_scores_gemma":[0.9986541,0.0001003209,0.0006672013,0.00004611735,0.0001047424,0.00001035504,0.00004138766,0.00003408045,0.0003416644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3179436,"threshold_uncertainty_score":0.6833389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02936806657727737,"score_gpt":0.3170936086635169,"score_spread":0.2877255420862395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}