{"id":"W1991590387","doi":"10.1182/blood-2007-03-077628","title":"Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin–mediated human T-cell adhesion","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Alberta; Massachusetts Institute of Technology; McGovern Institute for Brain Research, Massachusetts Institute of Technology; National Institutes of Health; National Heart, Lung, and Blood Institute; Brigham and Women's Hospital","keywords":"Rap1; Guanine nucleotide exchange factor; Cell adhesion; Integrin; Cell biology; Cell adhesion molecule; Jurkat cells; Intercellular Adhesion Molecule-1; Biology; T cell; Signal transduction; Receptor; Immunology; Cell; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004964508,0.000282193,0.0004440897,0.0004829095,0.000102107,0.00002980168,0.0001688363,0.000274847,0.0004875902],"category_scores_gemma":[0.000488824,0.0002526076,0.000112164,0.0003283932,0.00006455521,0.00007610573,0.0001782712,0.000472183,0.00007958236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000866862,"about_ca_system_score_gemma":0.0000801713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002470614,"about_ca_topic_score_gemma":0.0003815315,"domain_scores_codex":[0.9976418,0.00006474896,0.0004897391,0.0005533974,0.0005496279,0.0007007031],"domain_scores_gemma":[0.998601,0.0003270257,0.0001002601,0.0003289794,0.0002040799,0.0004386603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006459238,0.001284647,0.004892987,0.0003867843,0.00002915083,0.0003640824,0.0003824698,1.368214e-7,0.9902027,0.00002232775,0.0002133407,0.00157541],"study_design_scores_gemma":[0.01318618,0.001059266,0.02562164,0.0001164219,0.00008435537,0.00003580948,0.0002486069,0.0002255444,0.9558911,0.00001350196,0.003252073,0.0002655222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996145,0.00117018,0.00008708345,0.0002308546,0.0000751749,0.001313264,0.00008365442,0.00007323865,0.0008215361],"genre_scores_gemma":[0.9959829,0.0001907457,0.0002858407,0.000210363,0.0003035864,0.00006255589,0.0002037871,0.00007087988,0.002689318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03431167,"threshold_uncertainty_score":0.9999926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02758942954860961,"score_gpt":0.3115660283833283,"score_spread":0.2839765988347187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}