{"id":"W1991590387","doi":"10.1182/blood-2007-03-077628","title":"Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin–mediated human T-cell adhesion","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Alberta; Massachusetts Institute of Technology; McGovern Institute for Brain Research, Massachusetts Institute of Technology; National Institutes of Health; National Heart, Lung, and Blood Institute; Brigham and Women's Hospital","keywords":"Rap1; Guanine nucleotide exchange factor; Cell adhesion; Integrin; Cell biology; Cell adhesion molecule; Jurkat cells; Intercellular Adhesion Molecule-1; Biology; T cell; Signal transduction; Receptor; Immunology; Cell; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001228296,0.0003591373,0.0002096335,0.0002000757,0.0002030336,0.0003260566,0.0002026296,0.000365487,0.0008797559],"category_scores_gemma":[0.0001321096,0.0001764839,0.0002034049,0.00009927326,0.0002234402,0.0001529183,0.0001951878,0.0004421057,0.0005363707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002702639,"about_ca_system_score_gemma":0.0001983458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002696745,"about_ca_topic_score_gemma":0.0001921692,"domain_scores_codex":[0.9998951,0.00002693502,0.000009496505,0.00002402995,0.00001840201,0.00002605716],"domain_scores_gemma":[0.9999137,0.00001786101,0.00002565109,0.00001611744,0.000007159118,0.00001954138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001751155,0.00002116431,0.0001142728,0.00004519175,0.000004531032,0.0001097089,0.0000159026,0.00009605601,0.9975986,0.0002464483,0.00005836202,0.001514657],"study_design_scores_gemma":[0.00003816136,0.0001424273,0.00460787,0.00001337392,0.00003191562,0.0008688224,0.0000255267,0.001938095,0.9886929,0.0001184334,0.003517336,0.000005214271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915843,0.004500681,0.001837254,0.0002281717,0.0000297328,0.00002724436,0.0003393121,0.0001270661,0.0013261],"genre_scores_gemma":[0.9967744,0.001001485,0.001174559,0.00003808193,0.00001297604,0.00004265222,0.0003071077,0.00001430773,0.0006345579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008797559,"threshold_uncertainty_score":0.002943099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02758942954860961,"score_gpt":0.3115660283833283,"score_spread":0.2839765988347187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}