{"id":"W1991623589","doi":"10.1039/c1mb05075c","title":"Entropy and Mg2+ control ligand affinity and specificity in the malachite green binding RNA aptamer","year":2011,"lang":"en","type":"article","venue":"Molecular BioSystems","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"National Center for Research Resources; University of California, San Francisco; National Institutes of Health; National Science Council","keywords":"Aptamer; Isothermal titration calorimetry; Riboswitch; Chemistry; Ligand (biochemistry); RNA; Titration; Metal ions in aqueous solution; Biophysics; Stereochemistry; Metal; Biochemistry; Biology; Non-coding RNA; Inorganic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006268473,0.0002061439,0.0002177534,0.00006241087,0.00008942634,0.00005387778,0.0002125939,0.0001727946,0.000007564709],"category_scores_gemma":[0.00004366898,0.0001535338,0.00006364207,0.00008316994,0.00008779787,0.0000051461,0.00007632776,0.000101908,0.000007132821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006508085,"about_ca_system_score_gemma":0.00001425174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002443847,"about_ca_topic_score_gemma":0.00005651228,"domain_scores_codex":[0.9986178,0.0003196565,0.0002401564,0.0003964458,0.0001530013,0.0002729579],"domain_scores_gemma":[0.9994096,0.00001936292,0.0001011644,0.0003651599,0.00002601967,0.00007869511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008677177,0.00003495796,0.004029293,0.00003115685,0.00004262894,0.00003973838,0.0002603661,2.588697e-7,0.9933469,0.0008385556,0.00002111909,0.001268221],"study_design_scores_gemma":[0.0009288409,0.0002690502,0.003438281,0.00004502607,0.00003555948,0.00008983717,0.0003507412,0.00003260489,0.9918138,0.0002677247,0.002450441,0.0002780442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947819,0.00189866,0.001283255,0.0001696875,0.00009120625,0.0005167007,0.00002350346,0.000009461496,0.001225702],"genre_scores_gemma":[0.9990969,0.0001412394,0.0002706065,0.0002540748,0.00009215797,0.00004189394,0.000008615054,0.00002244772,0.00007208104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00431506,"threshold_uncertainty_score":0.6260926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01460573796715934,"score_gpt":0.2057924660858794,"score_spread":0.19118672811872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}