{"id":"W1991637447","doi":"10.1111/bjh.12066","title":"Activation of caspases‐9, ‐3 and ‐8 in human platelets triggered by <scp>BH</scp>3‐only mimetic <scp>ABT</scp>‐737 and calcium ionophore A23187: caspase‐8 is activated via bypass of the death receptors","year":2012,"lang":"en","type":"article","venue":"British Journal of Haematology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto Metropolitan University; Pediatric Oncology Group; St. Michael's Hospital","funders":"","keywords":"Apoptosis; Caspase; Cell biology; Platelet activation; Chemistry; Platelet; Intrinsic apoptosis; Mitochondrion; Caspase-9; Calcium; Programmed cell death; Biochemistry; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009466398,0.0001372614,0.0001303063,0.000158911,0.0001067462,0.0002040097,0.00008212127,0.0002081771,0.001071846],"category_scores_gemma":[0.0001148938,0.00008018567,0.0001467811,0.0001989426,0.0001598673,0.0001122462,0.00008643591,0.0003289306,0.0002846533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002369742,"about_ca_system_score_gemma":0.0001878707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006873643,"about_ca_topic_score_gemma":0.0005186349,"domain_scores_codex":[0.9998908,0.00002654069,0.00001124033,0.00001674453,0.00003080428,0.00002393879],"domain_scores_gemma":[0.9999592,0.00001204384,0.000008656313,0.000005908533,0.000006292595,0.000007814348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004462051,0.00003137076,0.000342095,0.00003893832,0.000007305048,0.0002494874,0.00004190532,0.00004548224,0.9969466,0.0001733389,0.00005177454,0.001625434],"study_design_scores_gemma":[0.00007567881,0.0005595455,0.01251218,0.000004833055,0.00002450704,0.00127163,0.00004727989,0.0005995269,0.9828356,0.0001719326,0.001891741,0.000005522834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958445,0.00147784,0.001254769,0.00006316681,0.00001362826,0.00003046303,0.000303312,0.00002306942,0.0009891837],"genre_scores_gemma":[0.9964799,0.0007592043,0.000885161,0.00002487631,0.000006420869,0.0000462135,0.000629703,0.000004048479,0.00116446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001071846,"threshold_uncertainty_score":0.003585637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01019532099496519,"score_gpt":0.2383654251272807,"score_spread":0.2281701041323154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}