{"id":"W1991637447","doi":"10.1111/bjh.12066","title":"Activation of caspases‐9, ‐3 and ‐8 in human platelets triggered by <scp>BH</scp>3‐only mimetic <scp>ABT</scp>‐737 and calcium ionophore A23187: caspase‐8 is activated via bypass of the death receptors","year":2012,"lang":"en","type":"article","venue":"British Journal of Haematology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto Metropolitan University; Pediatric Oncology Group; St. Michael's Hospital","funders":"","keywords":"Apoptosis; Caspase; Cell biology; Platelet activation; Chemistry; Platelet; Intrinsic apoptosis; Mitochondrion; Caspase-9; Calcium; Programmed cell death; Biochemistry; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003915192,0.000196616,0.000559875,0.000135742,0.0001065697,0.00001873594,0.0001575227,0.000412293,0.000008398216],"category_scores_gemma":[0.0002699678,0.000178143,0.0001177316,0.000154421,0.0001789605,0.00003112595,0.00009851861,0.0002471303,2.518562e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002340613,"about_ca_system_score_gemma":0.00007434444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002431283,"about_ca_topic_score_gemma":0.00004595845,"domain_scores_codex":[0.9983156,0.0002289877,0.000703387,0.0002294502,0.0001963605,0.0003261935],"domain_scores_gemma":[0.9985616,0.0001213291,0.0008207881,0.0001723669,0.0001895296,0.0001343475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003825491,0.0002535059,0.00676697,0.00009702196,0.0001361497,0.00006322088,0.0002538476,0.00001534858,0.9868884,0.00005545073,0.002585846,0.002845988],"study_design_scores_gemma":[0.001577198,0.0003473592,0.01932855,0.0001930542,0.00009049843,0.01252246,0.0003491182,0.00004836703,0.9630003,0.000216132,0.002258417,0.0000685161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932466,0.005789924,0.0003459015,0.00006300954,0.0002235564,0.000238729,0.00003063458,0.000003052239,0.00005866518],"genre_scores_gemma":[0.9985158,0.0009405372,0.0001888909,0.00006063228,0.00007399379,0.000004279424,0.00003986719,0.00002727516,0.0001487167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02388807,"threshold_uncertainty_score":0.726446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01019532099496519,"score_gpt":0.2383654251272807,"score_spread":0.2281701041323154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}