{"id":"W1991645653","doi":"10.1371/journal.pone.0062468","title":"Missense Variants of Uncertain Significance (VUS) Altering the Phosphorylation Patterns of BRCA1 and BRCA2","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; University of Toronto; Lunenfeld-Tanenbaum Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Missense mutation; Biology; Phosphorylation; DNA repair; Genetics; DNA damage; Kinase; Breast cancer; Transcription factor; Gene; Mutation; Cancer research; Cell biology; DNA; Bioinformatics; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005551832,0.0004448328,0.000530662,0.0007738866,0.0003843512,0.0003531828,0.0003032526,0.0005690446,0.002355502],"category_scores_gemma":[0.001736113,0.0001434701,0.0005508759,0.0008806331,0.00024998,0.0001677143,0.0004187857,0.0003709854,0.0003917397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001877128,"about_ca_system_score_gemma":0.0001914083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008643331,"about_ca_topic_score_gemma":0.002231081,"domain_scores_codex":[0.9994029,0.0001068562,0.00007948625,0.0001539418,0.0002062625,0.00005060072],"domain_scores_gemma":[0.9992946,0.0003501131,0.000200197,0.00005466415,0.00003634388,0.00006399658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005398995,0.000378864,0.3348513,0.001539774,0.001354245,0.02680515,0.000478457,0.01242458,0.4706529,0.001706369,0.003225822,0.1411837],"study_design_scores_gemma":[0.0002992039,0.001698914,0.5738741,0.0002649669,0.001649904,0.09796643,0.0005197017,0.03904445,0.256132,0.002723691,0.02562911,0.0001974483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838689,0.002299235,0.008466483,0.00009978101,0.00006585412,0.00006509938,0.003736683,0.0003368846,0.001061124],"genre_scores_gemma":[0.9922658,0.0003447539,0.005124669,0.0000535472,0.00001230354,0.00002074563,0.001864928,0.00003637684,0.0002768844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002355502,"threshold_uncertainty_score":0.007879972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02603827350157534,"score_gpt":0.236142046438691,"score_spread":0.2101037729371156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}