{"id":"W1991661989","doi":"10.1182/blood-2003-07-2617","title":"A novel SHP-1/Grb2–dependent mechanism of negative regulation of cytokine-receptor signaling: contribution of SHP-1 C-terminal tyrosines in cytokine signaling","year":2003,"lang":"en","type":"article","venue":"Blood","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; Ontario Institute for Cancer Research","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Cell biology; Proto-oncogene tyrosine-protein kinase Src; GRB2; Biology; Cytokine receptor; Suppressor of cytokine signaling 1; Receptor tyrosine kinase; SH2 domain; Signal transduction; Protein tyrosine phosphatase; SOCS3; ROR1; Tyrosine kinase; SOCS2; Immunoreceptor tyrosine-based activation motif; Janus kinase 2; Receptor; Platelet-derived growth factor receptor; Biochemistry; STAT3; Growth factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001922354,0.0006270751,0.0002298558,0.0001974469,0.0001942137,0.0003933936,0.0004405981,0.0003746811,0.0006657071],"category_scores_gemma":[0.00007941692,0.0001479092,0.0002596648,0.00009908789,0.000388876,0.0003928769,0.0003215027,0.0008192292,0.0002182814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003558317,"about_ca_system_score_gemma":0.0001583214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001924188,"about_ca_topic_score_gemma":0.0002239758,"domain_scores_codex":[0.9998729,0.0000144506,0.000007697186,0.00003098643,0.00003988211,0.00003400364],"domain_scores_gemma":[0.9999421,0.000006633836,0.00002151186,0.000008341957,0.000007160599,0.00001432997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007201405,0.00002921877,0.0002492545,0.00006153452,0.000007709966,0.000204866,0.00001212044,0.0001573179,0.9963886,0.0007197327,0.0001003376,0.001997424],"study_design_scores_gemma":[0.00005427922,0.0002058438,0.005264433,0.000008989037,0.00002462873,0.001077966,0.00002020837,0.005145011,0.9841737,0.0004122835,0.003599466,0.00001318258],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.969846,0.006386038,0.01999312,0.0003955833,0.0001407153,0.00008608129,0.0003675144,0.0003439802,0.002440975],"genre_scores_gemma":[0.9926313,0.001573486,0.00302765,0.0001103177,0.00003875295,0.00005018306,0.0003137255,0.0000128944,0.002241635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006657071,"threshold_uncertainty_score":0.002581716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02048605050537535,"score_gpt":0.263049696937156,"score_spread":0.2425636464317807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}