{"id":"W1991661989","doi":"10.1182/blood-2003-07-2617","title":"A novel SHP-1/Grb2–dependent mechanism of negative regulation of cytokine-receptor signaling: contribution of SHP-1 C-terminal tyrosines in cytokine signaling","year":2003,"lang":"en","type":"article","venue":"Blood","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; Ontario Institute for Cancer Research","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Cell biology; Proto-oncogene tyrosine-protein kinase Src; GRB2; Biology; Cytokine receptor; Suppressor of cytokine signaling 1; Receptor tyrosine kinase; SH2 domain; Signal transduction; Protein tyrosine phosphatase; SOCS3; ROR1; Tyrosine kinase; SOCS2; Immunoreceptor tyrosine-based activation motif; Janus kinase 2; Receptor; Platelet-derived growth factor receptor; Biochemistry; STAT3; Growth factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006044621,0.0002705583,0.0008091822,0.0004527753,0.00004939689,0.00000911732,0.0001092553,0.0001849484,0.0003606607],"category_scores_gemma":[0.0007551696,0.0002569265,0.0002481902,0.0005590328,0.0001029574,0.0001562592,0.00003274315,0.0002488059,0.000003382464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007980975,"about_ca_system_score_gemma":0.0002129315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002726758,"about_ca_topic_score_gemma":0.00003939966,"domain_scores_codex":[0.9974973,0.0001034081,0.001212941,0.0003594698,0.0005336755,0.0002932115],"domain_scores_gemma":[0.9976872,0.0002489757,0.0008037502,0.0003074504,0.0008549484,0.00009770664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004659593,0.00204903,0.002500697,0.0001863449,0.0001641158,0.000008157647,0.0005095031,0.000405012,0.9850396,0.008582524,0.00001058692,0.00007848218],"study_design_scores_gemma":[0.008009952,0.001017304,0.001975913,0.001318756,0.000389562,0.0001058703,0.0003240162,0.0005046505,0.9854311,0.0006720826,0.00005248845,0.0001983266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867923,0.0001479308,0.01159652,0.00006190088,0.0001908439,0.0006426172,0.0002306494,0.00002786297,0.0003093516],"genre_scores_gemma":[0.9950382,0.00001581438,0.004587978,0.00002279483,0.000110371,0.00002981576,0.0001022017,0.00003414687,0.00005874413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008245806,"threshold_uncertainty_score":0.9999883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02048605050537535,"score_gpt":0.263049696937156,"score_spread":0.2425636464317807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}