{"id":"W1991682877","doi":"10.1016/j.jneuroim.2014.08.615","title":"Gold drug auranofin could reduce neuroinflammation by inhibiting microglia cytotoxic secretions and primed respiratory burst","year":2014,"lang":"en","type":"article","venue":"Journal of Neuroimmunology","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Fondation pour la Recherche sur Alzheimer","keywords":"Auranofin; Neuroinflammation; Microglia; Apocynin; Pharmacology; Neuroprotection; Respiratory burst; Tumor necrosis factor alpha; Nitric oxide; Cytotoxic T cell; Immunology; Medicine; NADPH oxidase; Inflammation; Biology; Rheumatoid arthritis; In vitro; Internal medicine; Biochemistry; Oxidative stress","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006840338,0.0002906392,0.0004097914,0.0004301246,0.0003160355,0.0001696088,0.0003901148,0.00012888,0.00003102941],"category_scores_gemma":[0.002073095,0.0002872007,0.0001216224,0.0003501225,0.0002407937,0.0006066728,0.0001168597,0.0007898304,0.00003651445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004197639,"about_ca_system_score_gemma":0.00008582756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001500072,"about_ca_topic_score_gemma":0.00000149106,"domain_scores_codex":[0.9964396,0.001221661,0.001091852,0.0004747746,0.0003612223,0.0004108364],"domain_scores_gemma":[0.9975173,0.0006475697,0.001138083,0.0003209078,0.0002014109,0.0001746911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009506894,0.00005359175,0.00002181376,0.00001717576,0.000004375794,0.00004927112,0.0001121321,0.00004594077,0.9927084,0.003548099,0.002362794,0.0009813291],"study_design_scores_gemma":[0.001250545,0.000477442,0.000760307,0.00003098931,0.0000232178,0.001132739,0.0000269439,0.0007950015,0.9711525,0.0006565315,0.02347379,0.0002199382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932913,0.0001205204,0.0006636622,0.004132802,0.0008239626,0.0002702667,0.000008866466,0.00009602027,0.0005926004],"genre_scores_gemma":[0.9952539,0.0001742664,0.0001531762,0.003501789,0.000227721,0.000007353997,0.00000279522,0.00005667065,0.0006222998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02155585,"threshold_uncertainty_score":0.999958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02337020148974005,"score_gpt":0.2572148531161135,"score_spread":0.2338446516263735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}