{"id":"W1991688187","doi":"10.1056/nejmoa1112168","title":"Tofacitinib, an Oral Janus Kinase Inhibitor, in Active Ulcerative Colitis","year":2012,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":799,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Pfizer","keywords":"Tofacitinib; Ulcerative colitis; Medicine; Janus kinase inhibitor; Placebo; Gastroenterology; Internal medicine; Inflammatory bowel disease; Clinical endpoint; Colitis; Pharmacokinetics; Pharmacology; Clinical trial; Rheumatoid arthritis; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001448152,0.0004572776,0.001356649,0.0003281939,0.0002560819,0.000449447,0.0003440613,0.0006539748,0.001906452],"category_scores_gemma":[0.0009401803,0.0002394612,0.0005108217,0.0003772083,0.0004812681,0.000474919,0.0001795263,0.001274051,0.0002283788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003802744,"about_ca_system_score_gemma":0.0004070741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004839104,"about_ca_topic_score_gemma":0.001239346,"domain_scores_codex":[0.9997125,0.0001464318,0.00003178484,0.00003582729,0.00003506751,0.00003832784],"domain_scores_gemma":[0.9995083,0.00019471,0.0001148771,0.00001731226,0.00002676936,0.0001380796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4038608,0.01472898,0.02074259,0.00388449,0.00157928,0.0007684725,0.0003246715,0.002123839,0.03645338,0.0004507847,0.004640495,0.5104421],"study_design_scores_gemma":[0.5754817,0.336457,0.06207148,0.000472955,0.002163907,0.002004746,0.0001498648,0.001925028,0.005335337,0.0005684242,0.01331887,0.00005064754],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9540337,0.04210366,0.0002748774,0.0006991621,0.0001401222,0.0003969145,0.0002039474,0.00003626418,0.002111231],"genre_scores_gemma":[0.9843072,0.01301519,0.0005725037,0.0005006576,0.0003419317,0.0002318286,0.000267224,0.000005107323,0.0007584755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001906452,"threshold_uncertainty_score":0.00765866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01462163763133877,"score_gpt":0.2802155893634397,"score_spread":0.2655939517321009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}