{"id":"W1991688187","doi":"10.1056/nejmoa1112168","title":"Tofacitinib, an Oral Janus Kinase Inhibitor, in Active Ulcerative Colitis","year":2012,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":799,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Pfizer","keywords":"Tofacitinib; Ulcerative colitis; Medicine; Janus kinase inhibitor; Placebo; Gastroenterology; Internal medicine; Inflammatory bowel disease; Clinical endpoint; Colitis; Pharmacokinetics; Pharmacology; Clinical trial; Rheumatoid arthritis; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006598216,0.0001358108,0.0002178445,0.00009353414,0.00003003766,0.000006380072,0.0001114098,0.00008801376,0.0001432946],"category_scores_gemma":[0.0003304576,0.0001032901,0.00004652812,0.00006231702,0.00009038602,0.00002721912,0.00002435887,0.0001994427,0.000003138686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003495377,"about_ca_system_score_gemma":0.0001985558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004529919,"about_ca_topic_score_gemma":0.0002768293,"domain_scores_codex":[0.9988591,0.0002312301,0.0003338766,0.0001074917,0.0002164017,0.0002518817],"domain_scores_gemma":[0.9990712,0.00002190733,0.0001779656,0.0001339295,0.0001423485,0.0004526411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0391847,0.001182909,0.2693573,0.00009781704,0.0004201864,0.003851676,0.01518475,0.0001477996,0.2418725,0.001022865,0.02595478,0.4017227],"study_design_scores_gemma":[0.05111602,0.002169693,0.8192229,0.0001779739,0.00008695083,0.0006751281,0.001370825,0.00001333397,0.03808745,0.0003008495,0.08647537,0.0003035283],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974738,0.0003164044,0.0001012428,0.0003792701,0.0005173078,0.00009805639,0.00001328648,0.000002625563,0.001098007],"genre_scores_gemma":[0.9937614,0.0000675473,0.0001794648,0.0004207055,0.005385978,0.000001933236,0.00003270384,0.00001353413,0.0001367546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5498656,"threshold_uncertainty_score":0.421205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01462163763133877,"score_gpt":0.2802155893634397,"score_spread":0.2655939517321009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}