{"id":"W1991704845","doi":"10.1371/journal.pone.0077060","title":"Long Chain Fatty Acyl-CoA Synthetase 4 Is a Biomarker for and Mediator of Hormone Resistance in Human Breast Cancer","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; School of Medicine, New York University; York University; National Center for Research Resources; Office of Research and Development; U.S. Department of Veterans Affairs; U.S. Department of Defense","keywords":"Breast cancer; SKBR3; Cancer research; Estrogen receptor; Biology; Cancer; Endocrinology; Steroid hormone receptor; Tamoxifen; Internal medicine; Lapatinib; Trastuzumab; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000125279,0.0001303873,0.0002565072,0.00005095372,0.0000382114,0.00001180636,0.0001037242,0.0001086353,0.00004367335],"category_scores_gemma":[0.00003894791,0.0001246167,0.0000506637,0.00006842702,0.0001003111,0.0000073053,0.00005314295,0.00004631017,0.00000122038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000137403,"about_ca_system_score_gemma":0.00004562756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003298321,"about_ca_topic_score_gemma":0.0009409113,"domain_scores_codex":[0.9991199,0.00002530283,0.0002195074,0.0002909214,0.0001229998,0.0002214127],"domain_scores_gemma":[0.9994348,0.00001421598,0.00009617369,0.0002587177,0.0001106562,0.00008543666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001597125,0.0002647519,0.005773338,0.0001408526,0.0001278964,6.369413e-8,0.0001197374,8.00032e-8,0.9848363,0.00003450969,0.007951798,0.0005909992],"study_design_scores_gemma":[0.002417421,0.00009398872,0.20507,0.000169955,0.0001429069,0.0000014928,0.00007121585,0.00003733315,0.784237,0.0001767702,0.007225988,0.0003558516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861411,0.01197398,0.00004756573,0.0006166984,0.0001401826,0.0004993599,0.0004871555,0.000005691812,0.00008827066],"genre_scores_gemma":[0.9941742,0.002532021,0.0006790328,0.0001967473,0.001345535,0.0003930719,0.00005318059,0.0000265698,0.000599626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2005992,"threshold_uncertainty_score":0.508172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01809711013866459,"score_gpt":0.2437427007679248,"score_spread":0.2256455906292603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}