{"id":"W1991720664","doi":"10.1038/nsmb.1876","title":"Tissue- and age-specific DNA replication patterns at the CTG/CAG-expanded human myotonic dystrophy type 1 locus","year":2010,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital; Hospital for Sick Children; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research","keywords":"Biology; Replication timing; Myotonic dystrophy; DNA replication; CTCF; Trinucleotide repeat expansion; Genetics; Locus (genetics); Replication (statistics); DNA replication factor CDT1; Chromatin; Molecular biology; DNA; Control of chromosome duplication; Virology; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006484878,0.000269356,0.0002034079,0.00006345638,0.0003734762,0.0000638819,0.0004738529,0.0003149057,0.0001943539],"category_scores_gemma":[0.0002662854,0.0001803671,0.00006362263,0.0001947647,0.0004735441,0.00003329144,0.0002498318,0.0007264307,0.00001926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002320691,"about_ca_system_score_gemma":0.00002111477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001042733,"about_ca_topic_score_gemma":0.00004848784,"domain_scores_codex":[0.9980205,0.0002738732,0.0002089558,0.0009755518,0.0001747328,0.000346409],"domain_scores_gemma":[0.9986171,0.00005895799,0.0001320525,0.001001724,0.00008207322,0.0001081682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002856033,0.000005760343,0.0009281802,0.000004728345,0.000005843804,0.00003122926,0.00003436763,0.00000273052,0.9884958,0.007926917,0.0001424129,0.002393482],"study_design_scores_gemma":[0.0002650349,0.0001565963,0.03425775,0.00000218693,0.0000152444,0.0001082035,0.000004617747,0.000006574393,0.9575097,0.002753135,0.004727575,0.0001933939],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969968,0.0005124778,0.00004352431,0.0009363732,0.0007920468,0.0004707676,0.00006646985,0.00005643659,0.0001251539],"genre_scores_gemma":[0.9979392,0.00003513393,0.00008704629,0.001454591,0.0001561321,0.0000236887,0.0000983468,0.0000303373,0.0001755168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03332957,"threshold_uncertainty_score":0.7355156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01135940079993569,"score_gpt":0.317515621208015,"score_spread":0.3061562204080793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}