{"id":"W1991730868","doi":"10.1073/pnas.0703012104","title":"Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain","year":2007,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"","keywords":"Ubiquitin; HAMP domain; Protein kinase domain; Kinase; Biophysics; Cell biology; Domain (mathematical analysis); Chemistry; Plasma protein binding; Binding domain; Biochemistry; Binding site; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002053647,0.00007842249,0.00008363814,0.0000384577,0.0001982659,0.00001625996,0.0003211194,0.00006216498,0.000008138167],"category_scores_gemma":[0.0002608611,0.00003823111,0.00004523064,0.000218224,0.001061063,0.00003569205,0.0001303453,0.0001118388,1.788914e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001399311,"about_ca_system_score_gemma":0.0000407804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005096478,"about_ca_topic_score_gemma":0.000001685645,"domain_scores_codex":[0.9989749,0.00002013428,0.0002502096,0.0001490825,0.0005024976,0.000103203],"domain_scores_gemma":[0.9991511,0.00008515314,0.0004363168,0.00001443744,0.0002919495,0.0000210775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001900334,0.00005552431,0.00365491,0.00008745968,0.00001507988,2.62792e-9,0.0005557371,0.000004996235,0.989409,0.004565253,0.00009373233,0.00136822],"study_design_scores_gemma":[0.0002508637,0.00009756728,0.05118357,0.00008555478,0.000007029049,0.00001505964,0.001258382,0.00002511454,0.9329879,0.01353861,0.0004942766,0.00005611009],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950081,0.00006475262,0.00001356628,0.001761707,0.00001277012,0.0003545996,0.0000471981,0.000002385434,0.00273493],"genre_scores_gemma":[0.9985676,0.00001114946,0.001160559,0.0001856405,0.00004744595,0.00001201084,0.000001815483,0.000002474492,0.00001126529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0564212,"threshold_uncertainty_score":0.390953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03432386567359689,"score_gpt":0.2769316768324753,"score_spread":0.2426078111588784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}