{"id":"W1991751528","doi":"10.1097/hjh.0000000000000479","title":"Genetic mechanisms of polygenic hypertension","year":2015,"lang":"en","type":"review","venue":"Journal of Hypertension","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Epistasis; Genetic architecture; Quantitative trait locus; Mendelian inheritance; Trait; Mechanism (biology); Genetics; Computational biology; Medicine; Evolutionary biology; Gene; Biology; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005880606,0.0006484666,0.000994096,0.001801478,0.00024992,0.0007830249,0.0008188421,0.000889134,0.002788812],"category_scores_gemma":[0.0007674767,0.0001576834,0.0004605093,0.001163527,0.0008694379,0.0007341764,0.000564806,0.001194744,0.001020409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006522429,"about_ca_system_score_gemma":0.001149332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001231828,"about_ca_topic_score_gemma":0.001427058,"domain_scores_codex":[0.9998457,0.00003551133,0.00001957038,0.00003691566,0.00004610595,0.00001610746],"domain_scores_gemma":[0.9996736,0.0001799609,0.00004195219,0.00001168584,0.00005979955,0.00003299932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.00008920535,0.00006038747,0.001553727,0.01055626,0.000218896,0.0008505417,0.0001138821,0.0005275305,0.001968979,0.01374349,0.02262167,0.9476955],"study_design_scores_gemma":[0.00003758904,0.0001245402,0.00848576,0.005111778,0.0003580778,0.008831051,0.0001492928,0.0002525599,0.0009865805,0.0211833,0.9544261,0.00005342414],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003684604,0.9968895,0.000518784,0.0008173728,0.0001453406,0.000006148804,0.00003400957,0.00001743102,0.001202893],"genre_scores_gemma":[0.002531558,0.9962288,0.0002705516,0.0002348283,0.0001862027,0.000007660326,0.00004433294,0.000002063403,0.0004939133],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002788812,"threshold_uncertainty_score":0.009329498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07143990203800663,"score_gpt":0.3049638003408576,"score_spread":0.233523898302851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}