{"id":"W1991769617","doi":"10.1006/mthe.2000.0135","title":"Targeting Transgene Expression to Airway Epithelia and Submucosal Glands, Prominent Sites of Human CFTR Expression","year":2000,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Neonatal Respiratory Health Research","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Transgene; Biology; Submucosal glands; Gene expression; Pathology; Respiratory epithelium; Genetic enhancement; Epithelium; Genetically modified mouse; Cystic fibrosis; Cytokeratin; Gene; Immunohistochemistry; Immunology; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001965843,0.0002309982,0.0002566272,0.0002151202,0.0001775937,0.0003099251,0.0001924085,0.000422129,0.001552822],"category_scores_gemma":[0.0002300116,0.0001570144,0.0001969023,0.0001473602,0.0003572897,0.0002489483,0.0002211172,0.0004893605,0.0006972246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002074301,"about_ca_system_score_gemma":0.0002984088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004843744,"about_ca_topic_score_gemma":0.0008359258,"domain_scores_codex":[0.9998628,0.00001837704,0.00001607152,0.00004201996,0.00003501847,0.00002561051],"domain_scores_gemma":[0.9998342,0.00003003501,0.00006473402,0.00001899201,0.00002091597,0.00003112965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001630031,0.000006996168,0.0001481951,0.00002955579,0.000001293737,0.00004682901,0.00001651288,0.00002048514,0.9977803,0.00009966874,0.00003854607,0.001795312],"study_design_scores_gemma":[0.00001816982,0.0003024185,0.005431478,0.00002821237,0.00002055176,0.001811211,0.00004141422,0.0004366721,0.9772974,0.0001064157,0.01449837,0.000007714533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9100962,0.006962082,0.07561349,0.0005622449,0.000108006,0.0002523964,0.0009643864,0.0007481022,0.004693066],"genre_scores_gemma":[0.9258863,0.006481867,0.0588313,0.0001959245,0.00003214544,0.0001800179,0.001108839,0.0001365213,0.007147022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001552822,"threshold_uncertainty_score":0.005194724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02829814666551315,"score_gpt":0.3461651710270281,"score_spread":0.3178670243615149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}