{"id":"W1991774082","doi":"10.1111/ejn.12093","title":"Use of catechol‐<i>O</i>‐methyltransferase inhibition to minimize L‐3,4‐dihydroxyphenylalanine‐induced dyskinesia in the 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐lesioned macaque","year":2013,"lang":"en","type":"article","venue":"European Journal of Neuroscience","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; Atuka (Canada); University Health Network; Baycrest Hospital","funders":"Parkinson Canada; Krembil Foundation; Edmond J. Safra Philanthropic Foundation; Parkinson Society Canada; Parkinson Study Group","keywords":"Entacapone; Dyskinesia; Catechol-O-methyl transferase; Parkinsonism; Pharmacology; Levodopa; Parkinson's disease; Medicine; Dopamine; Chemistry; Anesthesia; Internal medicine; Disease; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001119856,0.0004911801,0.0003245655,0.0001487575,0.0002207926,0.0004032862,0.0003371777,0.0004038292,0.0008447696],"category_scores_gemma":[0.00009553126,0.0001628752,0.0003102332,0.00009860678,0.0002822363,0.0002141057,0.0001512623,0.0006964739,0.0002397559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000519421,"about_ca_system_score_gemma":0.0004490979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002045667,"about_ca_topic_score_gemma":0.005679282,"domain_scores_codex":[0.9998947,0.00001168054,0.00001067716,0.00003025682,0.00001569096,0.00003686428],"domain_scores_gemma":[0.999887,0.00001224203,0.00003307528,0.0000148604,0.00001248527,0.00004031341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002601701,0.00009612672,0.0001174993,0.00003245358,0.00000744515,0.00003662095,0.00001840697,0.0000256007,0.9981453,0.00004476015,0.00003627506,0.001179235],"study_design_scores_gemma":[0.00007953511,0.001593477,0.002238475,0.000005131092,0.00002472762,0.0001529859,0.00001752757,0.0003570194,0.9941815,0.00002789754,0.001315861,0.000005931985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962589,0.000697212,0.001231976,0.0001453627,0.00004756074,0.0000711723,0.0002212481,0.00009641604,0.001230258],"genre_scores_gemma":[0.9930133,0.0006894468,0.00366028,0.00009950294,0.00001874831,0.0001097404,0.0003150815,0.00003310793,0.002060975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002045667,"threshold_uncertainty_score":0.00406754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05550086087036551,"score_gpt":0.2746690289280667,"score_spread":0.2191681680577011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}