{"id":"W1991785215","doi":"10.1371/journal.pone.0051305","title":"Amyloid Beta Precursor Protein and Prion Protein Have a Conserved Interaction Affecting Cell Adhesion and CNS Development","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Innovates; Alzheimer Society","keywords":"Zebrafish; Biology; Phenotype; Amyloid precursor protein; Gene knockdown; Cell biology; Immunoprecipitation; PRNP; Genetics; Alzheimer's disease; Gene; Disease; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001026045,0.0004970865,0.0002544122,0.0002960996,0.000195182,0.0003285072,0.0002354726,0.0003780327,0.0004620948],"category_scores_gemma":[0.0001232096,0.0001919842,0.000198761,0.000160424,0.0003192651,0.0002000485,0.0004982791,0.0003626551,0.0002973849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002305357,"about_ca_system_score_gemma":0.0002208054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004207691,"about_ca_topic_score_gemma":0.0007503908,"domain_scores_codex":[0.9997993,0.00002443393,0.00001415606,0.00004979228,0.00009102624,0.00002122622],"domain_scores_gemma":[0.9998883,0.00001125146,0.00005084269,0.00001485903,0.00001192744,0.00002275381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009600207,0.00000535586,0.0002020495,0.00001341958,0.000002911603,0.0001649075,0.000004333078,0.00001358112,0.9984938,0.000126675,0.00001337294,0.000950073],"study_design_scores_gemma":[0.0000107337,0.0004854292,0.04202772,0.00001077672,0.00004375081,0.008848103,0.00004026345,0.0009635199,0.9411826,0.0002974709,0.006074069,0.00001557036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821753,0.006630815,0.007779959,0.0001387982,0.00003180034,0.00002956103,0.0001267976,0.0001199689,0.002967065],"genre_scores_gemma":[0.9899415,0.001923441,0.004933947,0.00004617496,0.00001514778,0.00002857051,0.0002541092,0.00001308872,0.002844003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004970865,"threshold_uncertainty_score":0.001672685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03092776020812193,"score_gpt":0.2380365072123865,"score_spread":0.2071087470042645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}