{"id":"W1991810959","doi":"10.1053/j.gastro.2006.11.041","title":"Adalimumab for Maintenance of Clinical Response and Remission in Patients With Crohn’s Disease: The CHARM Trial","year":2006,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2250,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; St. Paul's Hospital; University of British Columbia","funders":"","keywords":"Adalimumab; Medicine; Placebo; Internal medicine; Crohn's disease; Adverse effect; Randomized controlled trial; Gastroenterology; Tumor necrosis factor alpha; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002051186,0.001140766,0.00305894,0.0002639619,0.0005815366,0.001248321,0.0005814224,0.001200314,0.002252737],"category_scores_gemma":[0.001835083,0.0003556252,0.00155163,0.0003463725,0.0007630127,0.001160762,0.0005859321,0.003961634,0.0005406108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009214279,"about_ca_system_score_gemma":0.0008830854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007381214,"about_ca_topic_score_gemma":0.001957633,"domain_scores_codex":[0.9992385,0.0003950538,0.00003765528,0.00008216783,0.00007093639,0.0001757022],"domain_scores_gemma":[0.9989568,0.000282422,0.0002040894,0.00008409235,0.00005481771,0.0004177463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9294857,0.001318937,0.003965355,0.0009695169,0.002216562,0.0001450345,0.0000715452,0.001065175,0.001615182,0.0005350427,0.006942842,0.05166916],"study_design_scores_gemma":[0.9187019,0.03967445,0.02865641,0.0002350009,0.002662687,0.0004349001,0.00008271127,0.002084959,0.0006862461,0.001156716,0.005561757,0.00006223923],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9634124,0.02473538,0.0004956803,0.003641204,0.001125074,0.0003401714,0.001109195,0.0001810734,0.004959822],"genre_scores_gemma":[0.9901152,0.003331618,0.0006971994,0.001822634,0.0008030512,0.0004265736,0.0009907658,0.00002121286,0.001791838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00305894,"threshold_uncertainty_score":0.01084787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00775839641657307,"score_gpt":0.2611711406707846,"score_spread":0.2534127442542116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}